Q2IX74

PR
Gene name
pepA
Protein name
Probable cytosol aminopeptidase
Names
Leucine aminopeptidase, LAP, Leucyl aminopeptidase
Species
Rhodopseudomonas palustris (strain HaA2)
KEGG Pathway
rpb:RPB_2481
EC number
3.4.11.1: Aminopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

116-187 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2IX74

Entry ID Method Resolution Chain Position Source
AF-Q2IX74-F1 Predicted AlphaFoldDB

No variants for Q2IX74

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2IX74

No associated diseases with Q2IX74

2 regional properties for Q2IX74

Type Name Position InterPro Accession
domain Peptidase M17, leucyl aminopeptidase, C-terminal 181 - 487 IPR000819
domain Peptidase M17, leucyl aminopeptidase, N-terminal 20 - 144 IPR008283

Functions

Description
EC Number 3.4.11.1 Aminopeptidases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
manganese ion binding Binding to a manganese ion (Mn).
metalloaminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPDAVKVGFV PFSVAARGTL VVLCDDALKF GPATSKALGV AVSTVKRAVA ASQFKGKSGS
70 80 90 100 110 120
ALDLLAPEGL KVGRLVVIGT GKAAALKDYD VLKLGGAIAG KIGAGDTAVT VIAELPGGAM
130 140 150 160 170 180
KPEQAAAIAS GILLRAYKFD RYKTKKKDDD ANALNANVSI AVADAAAAKK AFAPDSAVVD
190 200 210 220 230 240
GVILARELVN EPPNVLYPEE FAKRAAQLKK LGVDIQILDV KAMTQLKMGA LLGVSQGSAH
250 260 270 280 290 300
PGRTVIMRWN GGKRGEQPVA FVGKGVCFDT GGISIKPSAS MEDMKGDMGG AACVVGLMHA
310 320 330 340 350 360
LAARKAKVNV IGAIGLVENM PDGNAQRPGD IVTSMSGQTI EIINTDAEGR LVLADVLWYV
370 380 390 400 410 420
AQKHKPKFMV DLATLTGAIM VALGTDHAGL FSNNDELAER LTAVGVSTGE KVWRMPLGPE
430 440 450 460 470 480
YDKQIDSQFA DMKNTGSRNG GSITAAQFLQ RFVDNTPWAH LDIAGTAMGA PKNDINQSWG
490
SGYGVRLLNA LVAEYYEAKK