Q2IG40

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Anaeromyxobacter dehalogenans (strain 2CP-C)
KEGG Pathway
ade:Adeh_3784
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

425-494 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2IG40

Entry ID Method Resolution Chain Position Source
AF-Q2IG40-F1 Predicted AlphaFoldDB

No variants for Q2IG40

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2IG40

No associated diseases with Q2IG40

4 regional properties for Q2IG40

Type Name Position InterPro Accession
domain DHHA1 domain 763 - 899 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 684 - 726 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 586 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 739 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTPTAAEIR ELFQRYFEEH GHRRVASSSL VPQNDPTLLF TNAGMVQFKD VFTGRERRDY
70 80 90 100 110 120
SRATTAQKCV RAGGKHNDLE NVGFTARHHT FFEMMGNFSF GDYFKADAIA WAWELVTSPA
130 140 150 160 170 180
WLGIAKDRLA ATVFAGEGTL PWDEEAFELW KAQGVPVERI HKLGAKDNFW AMGDTGPCGP
190 200 210 220 230 240
CSELHYFQGN DVPCAEEQAG RKCQGVACDC DRWLEIWNLV FMQFERGQDG GLTPLPKPSI
250 260 270 280 290 300
DTGAGLERLA AVAQGKRSNY DTDLFRSIIH AVEGLSDKRY DAASDDGVSM RVIADHARAT
310 320 330 340 350 360
TFLVGDGVLP SNEGRGYVLR RIMRRAIRHG KRLGLERPFL AAVCGAVIDE MGAAYPETRE
370 380 390 400 410 420
NRAFIEKVAQ QEEESFRRTL DKGLAILEGE MRKLVPDATH DGKPATPAPD RARPIIDGKV
430 440 450 460 470 480
AFQLYDTFGF PLDLTRVIAA ERGFDVDEQG FDRHMAEQRA RSEWKGSGEQ GVDDLHKQIA
490 500 510 520 530 540
GELGEVKFLG YELPAARAQV KAILANGARV ARAGKGDKVE IVTDATPFYG ESGGQVGDVG
550 560 570 580 590 600
HITGAGLEIR VDDAQRPVPG LVTHVGEVLR GEVAVGDAVE LSVDDRRRDL VRANHSATHL
610 620 630 640 650 660
LQLALREVLG EHVKQAGSVV APDYLRFDFS HFQPVTEEEL AAVERRVNEL VRENAETETA
670 680 690 700 710 720
VLKLEEARHA GAMMIFGEKY GDVVRVVRIG PSKELCGGTH VRRSGDIAFF KIGSEESIAS
730 740 750 760 770 780
GVRRLVAYTG ARAVEVQQRE AEELRRAAAL LKAGALEVSQ KIEQTQRRVK DLERALEEAR
790 800 810 820 830 840
SKAAAAQSGD LAALAKDVGG AKVLAARVEG DGKALRELAD KLRDRLGKGV VALGAEQDGK
850 860 870 880 890 900
AILLVAVTRD LTARLKAGDL VKEAAKLVGG SGGGKPDMAQ AGGSDPAGLE KALEKVAELA
ARALA