Q2HWK7

PR
Gene name
DES
Protein name
Acyl-lipid omega-13 desaturase
Names
CrDES, Omega13 fatty acid desaturase
Species
Chlamydomonas reinhardtii (Chlamydomonas smithii)
KEGG Pathway
cre:CHLRE_10g453600v5
EC number
1.14.19.12: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

53-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2HWK7

Entry ID Method Resolution Chain Position Source
AF-Q2HWK7-F1 Predicted AlphaFoldDB

No variants for Q2HWK7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2HWK7

No associated diseases with Q2HWK7

3 regional properties for Q2HWK7

Type Name Position InterPro Accession
domain Cytochrome b5-like heme/steroid binding domain 19 - 75 IPR001199
domain Fatty acid desaturase domain 165 - 442 IPR005804
binding_site Cytochrome b5, heme-binding site 33 - 40 IPR018506

Functions

Description
EC Number 1.14.19.12 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
acyl-lipid omega-(9-4) desaturase Catalysis of the reaction: linoleoyl- + 2 ferrocytochrome b5 + O2 + 2 H(+) <=> pinolenoyl-
alpha-linolenate delta5 desaturase activity Catalysis of the reaction: alpha-linolenate + O2 + a reduced electron acceptor = coniferonate + 2 H2O + an oxidized electron acceptor.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water.

3 GO annotations of biological process

Name Definition
linoleic acid metabolic process The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
unsaturated fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.
unsaturated fatty acid metabolic process The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MCRPTDSDSG PALPSIPHQY WIIHGATYDL ASYIKSHPGG DEAILLGRGR DCTELFEQYH
70 80 90 100 110 120
VLNNKHLRVL ERFRVTLPAA KVATNNLKED MVSTISAFEG EEADAAAVVG IQQPAAPARV
130 140 150 160 170 180
AHQSDPFYED IKAMVRAHGN TKMSAPFVIL HCLHVVGLIW SMKLWWQGAF ISAFILPYFL
190 200 210 220 230 240
WVLCAAMVHD GGHFAHSKRP LVNKLLTHTG ALFTNSVGCW YLQHNILHHS YTNLVGKDGD
250 260 270 280 290 300
LDSHHPYMRI HPEQSMLPAN IHHAVRFFSH LIMYNFAHIG LTMISPLSYF RGVAAQKKGT
310 320 330 340 350 360
ADAKQAQDAQ TVAQYHSTVM LQLVTVGAFY ITPFLRFDFS RALLLTLLPT FMMSVAFMVI
370 380 390 400 410 420
AQVSHIQMDA EAPSADLEKL HWARRMALTS VDYSQESTLW AYLTIGLNMQ SLHHIVPGVS
430 440 450 460 470
YSQLPRLYPA YRAICEKHGI KLLERRNLAH AFWTHLQTLW VLSKTHSFVE VARKLA