Q2HJ98

PR
Gene name
FAHD1
Protein name
Acylpyruvase FAHD1, mitochondrial
Names
Fumarylacetoacetate hydrolase domain-containing protein 1, Oxaloacetate decarboxylase, OAA decarboxylase
Species
Bos taurus (Bovine)
KEGG Pathway
bta:509273
EC number
3.7.1.5: In ketonic substances
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2HJ98

Entry ID Method Resolution Chain Position Source
AF-Q2HJ98-F1 Predicted AlphaFoldDB

83 variants for Q2HJ98

Variant ID(s) Position Change Description Diseaes Association Provenance
rs453384304 8 S>A No EVA
rs439029080 13 W>G No EVA
rs452687639 15 K>N No EVA
rs475948711 17 I>N No EVA
rs475948711 17 I>T No EVA
rs444714520 20 V>G No EVA
rs463155704 27 H>P No EVA
rs473604842 29 R>G No EVA
rs442450466 30 E>* No EVA
rs459486996 32 Q>P No EVA
rs479652478 34 A>P No EVA
rs458819017 36 P>H No EVA
rs482084553 37 S>G No EVA
rs482084553 37 S>R No EVA
rs450843524 40 V>M No EVA
rs467137470 45 P>Q No EVA
rs446893658 45 P>T No EVA
rs452554819 56 V>E No EVA
rs452554819 56 V>G No EVA
rs135133201 58 V>G No EVA
rs475832305 59 P>A No EVA
rs475832305 59 P>T No EVA
rs527086553 60 A>T No EVA
rs455081850 61 Y>* No EVA
rs473791451 64 N>Y No EVA
rs442451800 66 H>Q No EVA
rs459354996 67 H>R No EVA
rs438502611 68 E>D No EVA
rs473168857 68 E>G No EVA
rs458704686 69 L>I No EVA
rs450780127 70 E>G No EVA
rs461288031 71 L>V No EVA
rs446868523 72 A>T No EVA
rs432430347 79 C>W No EVA
rs446107874 80 R>L No EVA
rs469366190 81 A>T No EVA
rs455069455 84 E>* No EVA
rs468926934 84 E>V No EVA
rs435969081 88 M>L No EVA
rs452841962 89 D>Y No EVA
rs473000358 91 V>L No EVA
rs438472946 92 A>D No EVA
rs438472946 92 A>G No EVA
rs475592178 96 L>M No EVA
rs444294381 97 C>G No EVA
rs444294381 97 C>R No EVA
rs461183823 100 M>L No EVA
rs481397525 101 T>N No EVA
rs136864199 101 T>P No EVA
rs440317164 104 D>V No EVA
rs460507113 105 V>G No EVA
rs446093882 106 Q>K No EVA
rs483002421 107 D>A No EVA
rs483002421 107 D>G No EVA
rs469353734 107 D>Y No EVA
rs448626259 109 C>G No EVA
rs448626259 109 C>S No EVA
rs468768432 109 C>Y No EVA
rs434248665 110 K>* No EVA
rs466546773 113 G>R No EVA
rs431990992 114 L>R No EVA
rs475528741 115 P>S No EVA
rs475528741 115 P>T No EVA
rs444229271 116 W>C No EVA
rs110324598 119 A>T No EVA
rs454683796 120 K>Q No EVA
rs460441964 122 F>L No EVA
rs440247047 122 F>S No EVA
rs477203053 127 P>Q No EVA
rs522132920 140 P>A No EVA
rs439588324 144 K>N No EVA
rs462869418 145 L>V No EVA
rs482889589 152 E>A No EVA
rs468755021 158 E>D No EVA
rs438501482 162 M>I No EVA
rs479263996 162 M>L No EVA
rs517819194 171 S>N No EVA
rs447953415 171 S>R No EVA
rs464873506 172 Y>S No EVA
rs445698091 180 E>D No EVA
rs468987318 181 E>K No EVA
rs454552186 214 F>L No EVA
rs474814672 216 V>L No EVA

No associated diseases with Q2HJ98

5 regional properties for Q2HJ98

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 171 - 179 IPR000629
domain Helicase, C-terminal 238 - 399 IPR001650
domain DEAD/DEAH box helicase domain 48 - 214 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 42 - 242 IPR014001
domain RNA helicase, DEAD-box type, Q motif 23 - 51 IPR014014

Functions

Description
EC Number 3.7.1.5 In ketonic substances
Subcellular Localization
  • Mitochondrion
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

5 GO annotations of molecular function

Name Definition
acetylpyruvate hydrolase activity Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate.
acylpyruvate hydrolase activity Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate.
fumarylpyruvate hydrolase activity Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+.
metal ion binding Binding to a metal ion.
oxaloacetate decarboxylase activity Catalysis of the reaction: oxaloacetate = pyruvate + CO2.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3TC72 Fahd2 Fumarylacetoacetate hydrolase domain-containing protein 2A Mus musculus (Mouse) PR
10 20 30 40 50 60
MAASRPLSRF WEWGKNIVCV GRNYADHVRE MQSAAPSEPV LFLKPSTAYA PEGSPVLVPA
70 80 90 100 110 120
YTRNLHHELE LAVVMGKRCR AVSEAAAMDY VAGYALCLDM TARDVQDECK KKGLPWTLAK
130 140 150 160 170 180
SFTASCPVSA FVPKEKIPDP HNLKLWLKVN GELRQEGETS SMIFSIPYII SYVSKIMTLE
190 200 210 220
EGDIILTGTP KGVGPVKEND EIQAGIHGVL SMKFKVERPE Y