Q2H731

PR
Gene name
NIP1
Protein name
Eukaryotic translation initiation factor 3 subunit C
Names
eIF3c, Eukaryotic translation initiation factor 3 93 kDa subunit homolog, eIF3 p93, Translation initiation factor eIF3, p93 subunit homolog
Species
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2H731

Entry ID Method Resolution Chain Position Source
AF-Q2H731-F1 Predicted AlphaFoldDB

No variants for Q2H731

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2H731

No associated diseases with Q2H731

2 regional properties for Q2H731

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 604 - 792 IPR000717
domain Eukaryotic translation initiation factor 3 subunit C, N-terminal domain 67 - 631 IPR008905

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.

3 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
translation initiation factor binding Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.

1 GO annotations of biological process

Name Definition
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRFFRGGDD SSSESSSDEE ELYSTSEEEE EEDQDQEESS EEEDEEESSD EDEGPKKTGL
70 80 90 100 110 120
SRFLVDQASS DSEGSDEEGA TKVKSAKDKR FDELEATITT IQNRQKIDDW GSIANEFDKL
130 140 150 160 170 180
NRQVVKLQDG GKAPKSYIKC IAELEDFLNE TLAKQKVTPK NKKLNATNAR GLNAVKQRIK
190 200 210 220 230 240
KNNKDYQAQI DAFRKDSDDF MESDEEEVPA PKTKVRFQEA AAPEEAAEDE DKGFARVDKR
250 260 270 280 290 300
GKAIPFSPES IQKHLRAIVE SRGRKNTDRG EQIKIMEELN KVAETPYLKI RVLQTLVSAR
310 320 330 340 350 360
FDLGSGTTTS MPLDHWKAAE RELAALLTLL ETHKDHVVIE GAEEWEDDDK TPILGPDDKY
370 380 390 400 410 420
IKVPGSVVSY IERLDDELTR SLQSIDPHTS EYIERLTDEA SLYNIILQGL LYYETIRKDA
430 440 450 460 470 480
SLEIPQESLN RIIQRRLDHV YFKPAQVVKI LEENAWKQVS SGVDSAITPR GASGDAGKLM
490 500 510 520 530 540
YTLCNYLFDN SEGIIRARAM LSQIYFLALH DEYYKARDMM LTSHLQESIA NFDVATQILY
550 560 570 580 590 600
NRTLVQVGLC AFRRGLVYDA QNTLQDICGS GRQKELLAQG VMMQRYNQVT PEQERLEKQR
610 620 630 640 650 660
QLPFHMHINL ELLECVYLTC SMLLEIPLLA QIGSSPDIKK RVISKTYRRM LEYHERQIFT
670 680 690 700 710 720
GPPENTRDHV MQASKALAAG EWKKATHFIH SIKIWDLMPS SEEIKAMLAK QIQEEGLRTY
730 740 750 760 770 780
LFTYAPFYDT LAIETLSTMF ELDSVKVSAV VSKMISHEEL AAALDQVTKT VIFRKGVELS
790 800 810 820 830 840
RLQSLALALS DKASALIETN ERTLEVRTQG SANAFSRKDG RQGGQRGGGQ RSGRGGARAG
850 860
GNAQRQAGGT QFTGGALGAA VRG