Q2GVK1

PR
Gene name
SSN8 (CHGG_08003)
Protein name
RNA polymerase II holoenzyme cyclin-like subunit
Names
Species
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

180-329 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2GVK1

Entry ID Method Resolution Chain Position Source
AF-Q2GVK1-F1 Predicted AlphaFoldDB

No variants for Q2GVK1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2GVK1

No associated diseases with Q2GVK1

2 regional properties for Q2GVK1

Type Name Position InterPro Accession
domain Cyclin, N-terminal 51 - 114 IPR006671
domain Cyclin-like domain 53 - 143 IPR013763

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

1 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAANYWESTQ RKHWQFTKQD LAAIRQRLDD EDPGLVQMFP LPQLRHLNIY FNQQINRLSK
70 80 90 100 110 120
RIGLRQQVMA TAQVYLKRFY TRIAIRQTNP YLVLTTVLYL ACKMEECPQH IRMMTQEARS
130 140 150 160 170 180
LWPSDLHGHD PARVGECEFS LISEMHSNLI VHQPYRSLLG VQDEFGLTQD EMSLAWTVIN
190 200 210 220 230 240
DHYMTDLPLL HPPHVVALTA VLLALVLRPS ANTPAAGGAG GNAGAAAAAA AAGAGGVAMA
250 260 270 280 290 300
ATALAQAQAQ VQARAAAIAA AGAGGGTPGF GSQGSQQQAG FSQGNSQGSL QGDSAAAEPK
310 320 330 340 350 360
KVTDPRLAKV QRFAAWLADS NIDIEAMVDC TQELISFYEC HEQYNDKHTK EQISRFIKAR
NLDK