Q2GSV2

PR
Gene name
PAN2
Protein name
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Names
PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2
Species
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KEGG Pathway
EC number
3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2GSV2

Entry ID Method Resolution Chain Position Source
AF-Q2GSV2-F1 Predicted AlphaFoldDB

No variants for Q2GSV2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2GSV2

No associated diseases with Q2GSV2

3 regional properties for Q2GSV2

Type Name Position InterPro Accession
domain Exonuclease, RNase T/DNA polymerase III 879 - 1063 IPR013520
domain PAN2, UCH domain 477 - 807 IPR028881
domain Ubiquitin specific protease domain 477 - 833 IPR028889

Functions

Description
EC Number 3.1.13.4 Exoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
PAN complex A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
nucleic acid binding Binding to a nucleic acid.
poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.

2 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDADWDEVTR IAFPAPGSND YPRPATALAF DTIAELLWAG NDRGRVVSFY GRDLQRYTAF
70 80 90 100 110 120
KIHPPSEGPV RQFLFHDKGV IALGTRSVHM AMRRGPTLWN IRHDEMENLQ CMSFTSKGAS
130 140 150 160 170 180
EIIVAGFQDT MFVIDVVKGE IVKQKSKYIC AATRTGCVDL LDPITFKTVR SWQAHASYIN
190 200 210 220 230 240
DMDAQNDFIV TCGGSLKQQA AQTYMLDPYV NVFDLKNMTS MKPMPFPPLA AHVRLHPRML
250 260 270 280 290 300
TTSIVTSQHG QMHVVDIMNP NTSNVRYANV MSFINLFEIA PSGEALAMAD TECNIHLWGS
310 320 330 340 350 360
PSKIHFTDMA IPIEMPKAEE PAPMLDWSPD TPLSSIGMPY YREQLFSAWP SDIISDIGAP
370 380 390 400 410 420
PVQLDPSFLA SLKQMEWGFY GRNSRGLRRN QVEDTRACMK PSMQPPKFLS EKARESAMSY
430 440 450 460 470 480
SAAVPDPKVE QVPESSTDEL ESLKPEAPPI YRNLEIKYSK FGVDDFDFGY YNKTQYAGLE
490 500 510 520 530 540
NHIPNSYANS LLQLIHYTPL LRNMALQHAA TACVTDLCLL CELGFVFDML QKAEGSTCQA
550 560 570 580 590 600
TNMFKALGAT PQAAPLGLLE EETHVPSLST MSQGLSRFLF DRINHDYRSI NPISTTLEQT
610 620 630 640 650 660
LFNLPQPPTP DELVSRVLAT SAVVTIKCMN CRSETTRPGT AQVNDLMYPP PKGSARGGRM
670 680 690 700 710 720
HKTTFSQVLK TGVERETASK GWCSRCQRYQ NLQMRKTIHS VPAVLAINSA ISSQEHRKLW
730 740 750 760 770 780
ATPGWLPEEI GIIVDQGQFF CFEGEDLKLH LQRGMHNITV YSLIGMVVNI ESSSPQKTHL
790 800 810 820 830 840
VSVINVAHAD AAPSAESKWH LFNDFSVRPI STAEALTFNA AWKLPAVLLF QVKAANNKTN
850 860 870 880 890 900
MDWKTKLDTS LLYQDLTPHS DEKTYHVLDL EAEPPGPDTI VGLDTEFVSL KQPEIQMNSD
910 920 930 940 950 960
GERETIRPMS HALARVSVVR GQGEHEGEAF IDDYIAIREP VVDYLTLYSG ITPGDLDPRT
970 980 990 1000 1010 1020
TKHNLVSLKV AYKKLWVLLN LGCKFLGHGL RQDFRVINIQ VPRAQVIDTI QVFYLKARLR
1030 1040 1050 1060 1070 1080
KLSLAFLAWF LLKEDIQLET HDSIEDARTA LKLYRKYLEF EDAGILEAML EDIYKVGRAT
1090 1100
NFKPPRKDDQ VIQRTDTPFL SR