Q2GQ93

PR
Gene name
DHH1 (CHGG_09861)
Protein name
ATP-dependent RNA helicase DHH1
Names
Species
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KEGG Pathway
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

356-510 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2GQ93

Entry ID Method Resolution Chain Position Source
AF-Q2GQ93-F1 Predicted AlphaFoldDB

No variants for Q2GQ93

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2GQ93

No associated diseases with Q2GQ93

5 regional properties for Q2GQ93

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 158 - 166 IPR000629
domain Helicase, C-terminal 222 - 382 IPR001650
domain DEAD/DEAH box helicase domain 36 - 200 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 30 - 226 IPR014001
domain RNA helicase, DEAD-box type, Q motif 11 - 39 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm, P-body
  • Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDRDVTNTKG LDFEDFGLKR DLLMGIFEAG FEKPSPIQEE SIPVALVGRD ILARAKNGTG
70 80 90 100 110 120
KTAAFVIPAL EKINPKVSKI QCLILVPTRE LAMQTSQVCK TLGKHLGINV MVTTGGTGLR
130 140 150 160 170 180
DDIVRLQDPV HIVVGTPGRI LDLAGKQVAD LSECPMFIMD EADKLLSIEF TPVIEQLLRF
190 200 210 220 230 240
HPKDRQVMLF SATFPISVKD FSDKNMTSPY EINLMDELTL RGITQYYAYV EEKQKVHCLN
250 260 270 280 290 300
TLFSKLQINQ SIIFCNSTNR VELLAKKITE LGYSCFYSHA KMAQQARNRV FHDFRNGVCR
310 320 330 340 350 360
NLVCSDLLTR GIDIQAVNVV INFDFPKNAE TYLHRIGRSG RYGHLGLAIN LINWDDRFNL
370 380 390 400 410 420
YNIERDLGTE IQPIPQTIDK SLYVYENPES IPRPISNLKP AGIQQQQQLS IPSTAVGRLA
430 440 450 460 470 480
GTGPPKRFWS VWPSRPRRVP RQSRPLWWPP WRTFPRLPAR AGWAPELRRP ARWPCAGPKP
490 500 510
ADIPCSAGLG LSLSHLFGAL GGVLTIAISS PP