Q2GJV5

PR
Gene name
pnp
Protein name
Polyribonucleotide nucleotidyltransferase
Names
Polynucleotide phosphorylase, PNPase
Species
Anaplasma phagocytophilum (strain HZ)
KEGG Pathway
aph:APH_0767
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

679-835 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2GJV5

Entry ID Method Resolution Chain Position Source
AF-Q2GJV5-F1 Predicted AlphaFoldDB

No variants for Q2GJV5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2GJV5

No associated diseases with Q2GJV5

9 regional properties for Q2GJV5

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 14 - 143 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 331 - 464 IPR001247-2
domain S1 domain 626 - 697 IPR003029
domain K Homology domain 560 - 625 IPR004087
domain K Homology domain, type 1 564 - 621 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 147 - 211 IPR015847-1
domain Exoribonuclease, phosphorolytic domain 2 469 - 537 IPR015847-2
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 246 - 327 IPR015848
domain RNA-binding domain, S1 628 - 697 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFDITRKCVE WGDRSLTIES GKIARQAGGA VVVDYGGTSV LATVVSQKSK EAVDFLPLTV
70 80 90 100 110 120
QFLAKSYAVG KIPGGFFKRE GKPSDRETLI SRIIDRSIRP LFPSGFSDEV AVVCNLLSYD
130 140 150 160 170 180
ASSPPETVAL IGASAALAIS GIPFHCPVAG ARIGYIRGEG RYILNPSADE LSVSALDMFY
190 200 210 220 230 240
ARTDTSILMV ESEAHELTEA EMLGALQFGH EHCEEIIKVI GEFAEEARKC APAEFVPCDL
250 260 270 280 290 300
STIIDSIGSD YKERFLVAYS EKEKKARVAK LDAVRASLTE DLRVKFLSES EGGSKYIAQD
310 320 330 340 350 360
IVYAMKTFER SLVRERVLES KSRIDGRAYD QIRNIEIEVD LISKAHGSAL FTRGDTQALV
370 380 390 400 410 420
ITALGTPQDE QIVDGFDGDK RERFLLHYNF PPYAVGEASA LRPPGRREIG HGKLAWRAIH
430 440 450 460 470 480
PVLPSKADFP YTIRVVSEIT ESDGSSSMAT VCGASLALMD TGVPLKSSVA GIAMGLIKEG
490 500 510 520 530 540
DRYAILSDIL GDEDYLGDMD FKVAGTREGI TALQMDMKVK GIDFAVLGTA LDQAKEGRFF
550 560 570 580 590 600
IIEKMDRVIK ESRGAVREHV PRMESMLIDK GKIKNVIGAG GKNVREICEK TGAKIEISQD
610 620 630 640 650 660
GTVMIYAVGR EAIESAKDMI TGIVSEPEVG KIYSGEVCEL AKYGAFVTFL GARKGLVHIS
670 680 690 700 710 720
EIRNEHINAV ADVLAVGDKV KVLVIDMDKD HIQLSMRRID QETGDQVDCE LYAPQRRNGV
730 740 750 760 770 780
AAGNTVGDSS VNGGGAGSVY VPRGDYGGAS AGRNGRGGGK RDGAAKSSSS AGNGGGRSSS
790 800 810 820 830
STRRRHSAGS SGYSSDSSSG NTKSSSSESS GGTGGRGRNG ANGDVQNGPA APKKPRFF