Q2GE40

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia sennetsu)
KEGG Pathway
nse:NSE_0367
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

387-436 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2GE40

Entry ID Method Resolution Chain Position Source
AF-Q2GE40-F1 Predicted AlphaFoldDB

No variants for Q2GE40

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2GE40

No associated diseases with Q2GE40

4 regional properties for Q2GE40

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 99 - 333 IPR002314
domain Anticodon-binding 373 - 433 IPR004154
domain Aminoacyl-tRNA synthetase, class II 42 - 343 IPR006195
domain Prokaryote proline-tRNA ligase core domain 21 - 333 IPR033730

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKNKTRVSEY YLPLMKNVSG EVKLRSHKYS LRAGLVKQCG AGLYSWLPLG LKVLRNIESV
70 80 90 100 110 120
IRQELDSMGM HEMLMPCIQL AKLWEESGRY SDYGKELLKF KDRHDNELLF GPTNEEVITA
130 140 150 160 170 180
IVRDDLASYK QLPKILYHIQ WKFRDEIRPR FGLMRAREFL MKDAYSFDVD QQSARISYNK
190 200 210 220 230 240
VYQSYLRIFK RLGLNPIPCR ANAGVIGGSL NHEFHITTTE GGEGKIFYPE EMGELVDEFC
250 260 270 280 290 300
KIDPSNEHAV SVMTEKLQEL FCFTEECNSS GIGNDNRICT AQGIEVGHIF LFGEKYSAPM
310 320 330 340 350 360
QARFSGRDGK KKNFYMGSYG IGISRLLAAI IEVHSDDKGI IWPESIAPFK IGLINLHGES
370 380 390 400 410 420
CGFAEEIFSK LDSVIYDDTA DSQGVKFARM DLIGVPFQII VGKNGPIHGT IELKYRLDSK
430
RESRSLNELV SLFSHT