Q2GCD8

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199)
KEGG Pathway
nar:Saro_0023
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

289-358 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2GCD8

Entry ID Method Resolution Chain Position Source
AF-Q2GCD8-F1 Predicted AlphaFoldDB

No variants for Q2GCD8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2GCD8

No associated diseases with Q2GCD8

7 regional properties for Q2GCD8

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 345 - 392 IPR000722-1
domain RNA polymerase, alpha subunit 389 - 486 IPR000722-2
domain RNA polymerase, N-terminal 236 - 515 IPR006592
domain RNA polymerase Rpb1, domain 3 490 - 643 IPR007066
domain RNA polymerase Rpb1, domain 1 15 - 343 IPR007080
domain RNA polymerase Rpb1, domain 5 762 - 1301 IPR007081
domain RNA polymerase Rpb1, domain 4 672 - 759 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNDLTKFTNQ IAKPETFDQI QIGLASPERI RSWSFGEIKK PETINYRTFK PERDGLFCAR
70 80 90 100 110 120
IFGPVKDYEC LCGKYKRMKY KGVVCEKCGV EVTVTKVRRE RMGHIELAAP VAHIWFLKSL
130 140 150 160 170 180
PSRIGLLLDM QLKQLERILY FESYVVIEPG LTPLEKYQLL TEDELLDAQD EYGEDAFSAG
190 200 210 220 230 240
IGAEAVKHML MNLDLVQEKE DLLQELATTK SELKPKKIIK RLKVVESFID SGNRPEWMIL
250 260 270 280 290 300
DVVPVIPPEL RPLVPLDGGR FATSDLNDLY RRVINRNNRL KRLIELRAPD IIVRNEKRML
310 320 330 340 350 360
QEAVDALFDN GRRGRVITGA NKRPLKSLSD MLKGKQGRFR QNLLGKRVDY SGRSVIVTGP
370 380 390 400 410 420
ELKLHQCGLP KKMALELFKP FIYARLDAKG LSMTLKQAKK WVEKERKEVW DILDEVIREH
430 440 450 460 470 480
PVMLNRAPTL HRLGIQAFEP VLIEGKAIQL HPLVCSAFNA DFDGDQMAVH VPLSLEAQLE
490 500 510 520 530 540
ARVLMMSTNN ILSPANGKPI IVPSQDMVLG IYYLSMDRAG EPGEGMMLAD MAEVHQALEA
550 560 570 580 590 600
KAVTLHSKIV ARVPQTDEDG NQYLKRFETT PGRMLIGECL PKSHKVPFEI VNRLLTKKEI
610 620 630 640 650 660
GDVIDQVYRH TGQKDTVLFA DAIMALGFRH AFKAGISFGK DDMIIPDSKD ALVAETKELV
670 680 690 700 710 720
ADYEQQYQDG LITQQEKYNK VIDAWSRCGD QVANAMMEEL KSSPIDPETG RQKPINAIYM
730 740 750 760 770 780
MSHSGARGSP AQMKQLAGMR GLMAKPSGEI IETPIISNFK EGLTVLEYFN STHGARKGLA
790 800 810 820 830 840
DTALKTANSG YLTRRLVDVS QDCVVIEEDC GTERALEMRA IVQGGSTIAS LGERILGRTL
850 860 870 880 890 900
AEDLIEAKSG EVIAQKGELL DEAAIAKIEA AGVQSARIRS PLVCEATQGV CGKCYGRDLA
910 920 930 940 950 960
RGTPVNIGEA VGVIAAQSIG EPGTQLTMRT FHIGGAAQVN EQSHLEAISD GTVQYRDIPT
970 980 990 1000 1010 1020
ITDKRGRRLS LARNGEIVVI DTEGRERAIH RVPYGTHLLH ENGAIISQGD RLAEWDPFTT
1030 1040 1050 1060 1070 1080
PVITEKPGIV RYQDLVDGKT LTEQTDEATG MSSRVVTENR AAGRGKKEDL RPRLTLLDEN
1090 1100 1110 1120 1130 1140
SGEAARYMMA PGTTLSVEDG QQVEAGDILA RASREAAKTR DITGGLPRVA ELFEARKPKD
1150 1160 1170 1180 1190 1200
NSIIAKIAGR IEFVRDYKAK RKIAIIPEEG EPVEYLVPKS RVIDVQEGDY VKKGDNLISG
1210 1220 1230 1240 1250 1260
SPDPHDILEV MGVEALAEYL VAEIQEVYRL QGVKINDKHI EVIVRQMLQK VEITNGGDTT
1270 1280 1290 1300 1310 1320
LLPGEQVDLE EMLETNGKLE EGQQPAEGKP VLLGITKASL QTRSFISAAS FQETTRVLTQ
1330 1340 1350 1360 1370 1380
AAVEGKKDSL IGLKENVIVG RLIPAGTGAG MNRMRVAASS RDAALRASYR KLQESLIAPA
1390 1400 1410 1420
TAAEEHAAEL AQGPEAAIGD DPLATVEGET HGTDADAGDY LIEGDEA