Q2G1G8

PR
Gene name
ptsG (glcA, SAOUHSC_00155)
Protein name
PTS system glucose-specific EIICBA component
Names
EIICBA-Glc, EII-Glc, EIICBA-Glc 1
Species
Staphylococcus aureus (strain NCTC 8325 / PS 47)
KEGG Pathway
sao:SAOUHSC_00155
EC number
2.7.1.199: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

472-556 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2G1G8

Entry ID Method Resolution Chain Position Source
AF-Q2G1G8-F1 Predicted AlphaFoldDB

No variants for Q2G1G8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2G1G8

No associated diseases with Q2G1G8

6 regional properties for Q2G1G8

Type Name Position InterPro Accession
domain Phosphotransferase system, sugar-specific permease EIIA type 1 535 - 655 IPR001127
domain Phosphotransferase system, IIB component, type 1 404 - 506 IPR001996
domain Phosphotransferase system, EIIC 13 - 344 IPR003352
domain PTS system glucose-specific IIBC component 3 - 502 IPR011299
domain Phosphotransferase system, EIIC component, type 1 3 - 414 IPR013013
conserved_site Phosphotransferase system EIIB, cysteine phosphorylation site 425 - 500 IPR018113

Functions

Description
EC Number 2.7.1.199 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
glucose transmembrane transporter activity Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
protein-phosphocysteine-sugar phosphotransferase activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.

2 GO annotations of biological process

Name Definition
phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRKKLFGQLQ RIGKALMLPV AILPAAGLLL AIGTAMQGES LQHYLPFIQN GGVQTVAKLM
70 80 90 100 110 120
TGAGGIIFDN LPMIFALGVA IGLAGGDGVA AIAAFVGYII MNKTMGDFLQ VTPKNIGDPA
130 140 150 160 170 180
SGYASILGIP TLQTGVFGGI IIGALAAWCY NKFYNINLPS YLGFFAGKRF VPIMMATTSF
190 200 210 220 230 240
ILAFPMALIW PTIQSGLNAF STGLLDSNTG VAVFLFGFIK RLLIPFGLHH IFHAPFWFEF
250 260 270 280 290 300
GSWKNAAGEI IHGDQRIFIE QIREGAHLTA GKFMQGEFPV MMFGLPAAAL AIYHTAKPEN
310 320 330 340 350 360
KKVVAGLMGS AALTSFLTGI TEPLEFSFLF VAPLLFFIHA VLDGLSFLTL YLLDLHLGYT
370 380 390 400 410 420
FSGGFIDYFL LGILPNKTQW WLVIPVGLVY AVIYYFVFRF LIVKLKYKTP GREDKQSQAA
430 440 450 460 470 480
TASATELPYA VLEAMGGKAN IKHLDACITR LRVEVNDKSK VDVPGLKDLG ASGVLEVGNN
490 500 510 520 530 540
MQAIFGPKSD QIKHEMQQIM NGQVVENPTT MEDDKDETVV VAEDKSATSE LSHIVHAPLT
550 560 570 580 590 600
GEVTPLSEVP DQVFSEKMMG DGIAIKPSQG EVRAPFNGKV QMIFPTKHAI GLVSDSGLEL
610 620 630 640 650 660
LIHIGLDTVK LNGEGFTLHV EEGQEVKQGD LLINFDLDYI RNHAKSDITP IIVTQGNITN
670 680
LDFKQGEHGN ISFGDQLFEA K