Q2FV87
Gene name |
glcB (SAOUHSC_02848) |
Protein name |
PTS system glucoside-specific EIICBA component |
Names |
|
Species |
Staphylococcus aureus (strain NCTC 8325 / PS 47) |
KEGG Pathway |
sao:SAOUHSC_02848 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2FV87
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2FV87-F1 | Predicted | AlphaFoldDB |
No variants for Q2FV87
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2FV87 | |||||
No associated diseases with Q2FV87
6 regional properties for Q2FV87
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphotransferase system, sugar-specific permease EIIA type 1 | 543 - 666 | IPR001127 |
| domain | Phosphotransferase system, IIB component, type 1 | 416 - 519 | IPR001996 |
| domain | Phosphotransferase system, EIIC | 13 - 356 | IPR003352 |
| domain | PTS system glucose-specific IIBC component | 2 - 515 | IPR011299 |
| domain | Phosphotransferase system, EIIC component, type 1 | 3 - 427 | IPR013013 |
| conserved_site | Phosphotransferase system EIIB, cysteine phosphorylation site | 443 - 513 | IPR018113 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| glucose transmembrane transporter activity | Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| protein-N(PI)-phosphohistidine-sugar phosphotransferase activity | Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. |
| protein-phosphocysteine-sugar phosphotransferase activity | Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphoenolpyruvate-dependent sugar phosphotransferase system | The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFKKLFGQLQ | RIGKALMLPV | AILPAAGILL | AFGNAMHNEQ | LVEIAPWLKN | DIIVMISSVM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EAAGQVVFDN | LPLLFAVGTA | LGLAGGDGVA | ALAALVGYLI | MNATMGKVLH | ITIDDIFSYA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGAKELSQAA | KEPAHALVLG | IPTLQTGVFG | GIIMGALAAW | CYNKFYNITL | PPFLGFFAGK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RFVPIVTSVV | AIATGVLLSF | AWPPIQDGLN | SLSNFLLNKN | LTLTTFIFGI | IERSLIPFGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HHIFYSPFWF | EFGSYTNHAG | ELVRGDQRIW | MAQLKDGVPF | TAGAFTTGKY | PFMMFGLPAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AFAIYKNARP | ERKKVVGGLM | LSAGLTAFLT | GITEPLEFSF | LFVAPVLYGI | HVLLAGTSFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VMHLLGVKIG | MTFSGGFIDY | ILYGLLNWDR | SHALLVIPVG | IVYAIVYYFL | FDFAIRKFKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KTPGREDEET | EIRNSSVAKL | PFDVLDAMGG | KENIKHLDAC | ITRLRVEVVD | KSKVDVAGIK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ALGASGVLEV | GNNMQAIFGP | KSDQIKHDMA | KIMSGEITKP | SETTVTEEMS | DEPVHVEALG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TTDIYAPGIG | QIIPLSEVPD | QVFAGKMMGD | GVGFIPEKGE | IVAPFDGTVK | TIFPTKHAIG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LESESGVEVL | IHIGIDTVKL | NGEGFESLIN | VDEKVTQGQP | LMKVNLAYLK | AHAPSIVTPM |
| 670 | 680 | ||||
| IITNLENKEL | VIEDVQDADP | GKLIMTVK |