Q2FHI8

PR
Gene name
topA
Protein name
DNA topoisomerase 1
Names
DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme
Species
Staphylococcus aureus (strain USA300)
KEGG Pathway
saa:SAUSA300_1143
EC number
5.6.2.1: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

289-386 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2FHI8

Entry ID Method Resolution Chain Position Source
AF-Q2FHI8-F1 Predicted AlphaFoldDB

No variants for Q2FHI8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2FHI8

No associated diseases with Q2FHI8

10 regional properties for Q2FHI8

Type Name Position InterPro Accession
domain DNA topoisomerase, type IA, domain 2 107 - 195 IPR003601
domain DNA topoisomerase, type IA, DNA-binding domain 249 - 519 IPR003602
domain TOPRIM domain 1 - 116 IPR006171
domain DNA topoisomerase, type IA, central 75 - 88 IPR013497-1
domain DNA topoisomerase, type IA, central 131 - 567 IPR013497-2
domain DNA topoisomerase, type IA, zn finger 599 - 633 IPR013498
active_site DNA topoisomerase, type IA, active site 286 - 308 IPR023406
repeat Topoisomerase C-terminal repeat 660 - 713 IPR025589-1
repeat Topoisomerase C-terminal repeat 719 - 770 IPR025589-2
domain DNA topoisomerase 1, TOPRIM domain 1 - 128 IPR034149

Functions

Description
EC Number 5.6.2.1 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADNLVIVES PAKAKTIEKY LGKKYKVIAS MGHVRDLPRS QMGVDTEDNY EPKYITIRGK
70 80 90 100 110 120
GPVVKELKKH AKKAKNVFLA SDPDREGEAI AWHLSKILEL EDSKENRVVF NEITKDAVKE
130 140 150 160 170 180
SFKNPREIEM NLVDAQQARR ILDRLVGYNI SPVLWKKVKK GLSAGRVQSV ALRLVIDREN
190 200 210 220 230 240
EIRNFKPEEY WTIEGEFRYK KSKFNAKFLH YKNKPFKLKT KKDVEKITAA LDGDQFEITN
250 260 270 280 290 300
VTKKEKTRNP ANPFTTSTLQ QEAARKLNFK ARKTMMVAQQ LYEGIDLKKQ GTIGLITYMR
310 320 330 340 350 360
TDSTRISDTA KVEAKQYITD KYGESYTSKR KASGKQGDQD AHEAIRPSST MRTPDDMKSF
370 380 390 400 410 420
LTKDQYRLYK LIWERFVASQ MAPAILDTVS LDITQGDIKF RANGQTIKFK GFMTLYVETK
430 440 450 460 470 480
DDSDSEKENK LPKLEQGDKV TATQIEPAQH YTQPPPRYTE ARLVKTLEEL KIGRPSTYAP
490 500 510 520 530 540
TIDTIQKRNY VKLESKRFVP TELGEIVHEQ VKEYFPEIID VEFTVNMETL LDKIAEGDIT
550 560 570 580 590 600
WRKVIDGFFS SFKQDVERAE EEMEKIEIKD EPAGEDCEIC GSPMVIKMGR YGKFMACSNF
610 620 630 640 650 660
PDCRNTKAIV KSIGVKCPKC NDGDVVERKS KKNRVFYGCS KYPECDFISW DKPIGRDCPK
670 680
CNQYLVENKK GKTTQVICSN CDYKEAAQK