Q29RS5

PR
Gene name
RARRES2
Protein name
Retinoic acid receptor responder protein 2
Names
Chemerin
Species
Bos taurus (Bovine)
KEGG Pathway
bta:508990
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

48-162 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q29RS5

Entry ID Method Resolution Chain Position Source
AF-Q29RS5-F1 Predicted AlphaFoldDB

51 variants for Q29RS5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs472099857 2 W>G No EVA
rs444405039 10 L>R No EVA
rs434048443 12 L>R No EVA
rs455775190 12 L>V No EVA
rs467070990 14 T>P No EVA
rs432996720 16 G>A No EVA
rs450707388 19 R>G No EVA
rs480359448 20 A>G No EVA
rs480359448 20 A>V No EVA
rs876282426 27 H>P No EVA
rs467987186 32 V>G No EVA
rs479527572 37 F>L No EVA
rs457789997 44 L>P No EVA
rs438941166 47 F>L No EVA
rs478458461 50 T>P No EVA
rs463193728 54 N>K No EVA
rs480815211 64 Q>P No EVA
rs462408143 66 V>L No EVA
rs447089343 67 R>G No EVA
rs458053488 72 L>R No EVA
rs439579998 77 C>R No EVA
rs468969857 94 R>* No EVA
rs473277674 104 L>P No EVA
rs458081202 105 D>N No EVA
rs439321793 105 D>V No EVA
rs469888042 126 E>G No EVA
rs436870863 126 E>K No EVA
rs435788180 127 L>P No EVA
rs435788180 127 L>R No EVA
rs457438627 127 L>V No EVA
rs468809023 128 D>A No EVA
rs447126187 128 D>E No EVA
rs468809023 128 D>G No EVA
rs479949828 129 D>A No EVA
rs384157091 132 D>E No EVA
rs446022064 132 D>G No EVA
rs441755227 133 A>D No EVA
rs463872567 133 A>P No EVA
rs481254599 134 Q>R No EVA
rs459528839 135 C>S No EVA
rs441119894 135 C>W No EVA
rs470914684 136 S>N No EVA
rs452089786 136 S>R No EVA
rs443263336 137 R>M No EVA
rs476258713 138 V>G No EVA
rs133604819 144 D>A No EVA
rs381055249 147 S>G No EVA
rs475233276 149 Y>F No EVA
rs453475583 154 F>L No EVA
rs435019693 157 I>F No EVA
rs445961081 163 P>G No EVA

No associated diseases with Q29RS5

No regional properties for Q29RS5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q29RS5

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
collagen-containing extracellular matrix An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
extracellular matrix A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

17 GO annotations of biological process

Name Definition
antifungal humoral response An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster.
antifungal innate immune response An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
embryonic digestive tract development The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
insulin receptor signaling pathway The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
positive regulation of chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of fat cell differentiation Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
positive regulation of macrophage chemotaxis Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
regulation of insulin receptor signaling pathway Any process that modulates the frequency, rate or extent of insulin receptor signaling.
regulation of lipid catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
retinoid metabolic process The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9DD06 Rarres2 Retinoic acid receptor responder protein 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MWQLLLPLAL GLGTMGLGRA ELTTAQHRGL QVALEEFHKH PPVLWAFQVT SVDNAADTLF
70 80 90 100 110 120
PAGQFVRLEF KLQQTSCRKK DWRKEDCKVK PNGRKRKCLA CIKLDSKDQV LGRMVHCPIQ
130 140 150 160
TQVQRELDDA QDAQCSRVER AGEDPHSYYL PGQFAFIKAL SP