Q29FC1

PR
Gene name
Gen (GA10481)
Protein name
Flap endonuclease GEN
Names
Flap structure-specific endonuclease GEN, Xpg-like endonuclease
Species
Drosophila pseudoobscura pseudoobscura (Fruit fly)
KEGG Pathway
dpo:Dpse_GA10481
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

478-558 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q29FC1

Entry ID Method Resolution Chain Position Source
AF-Q29FC1-F1 Predicted AlphaFoldDB

No variants for Q29FC1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q29FC1

No associated diseases with Q29FC1

4 regional properties for Q29FC1

Type Name Position InterPro Accession
domain XPG, N-terminal 1 - 95 IPR006085
domain XPG-I domain 130 - 222 IPR006086
conserved_site Helix-hairpin-helix motif, class 2 209 - 243 IPR008918
domain Flap endonuclease GEN, chromatin organization modifier domain 404 - 476 IPR041012

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name Definition
5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule.
5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
crossover junction endodeoxyribonuclease activity Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
double-stranded DNA 3'-5' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule.
endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
four-way junction DNA binding Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
metal ion binding Binding to a metal ion.
single-stranded DNA 3'-5' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule.

3 GO annotations of biological process

Name Definition
DNA catabolic process, endonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
DNA catabolic process, exonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGVKELWTVL TPHAERKPIN ELRGKKVAID LAGWVCESLN VVDYFVHPRH HLKNLFFRTC
70 80 90 100 110 120
YLIWEQVTPV FVLEGVAPKL KGQVIAKRNE LQFRGVRPKD AATGTQTAAK VDKGRTRFNH
130 140 150 160 170 180
VLKQCETLLL SMGIQCVQGP GEAEAYAAFL NKHGLVDGVI SQDSDCFAYG AIRVYRNFSV
190 200 210 220 230 240
STQGAQAAAG GAVDIYDMRE ITSRMDFGQH KIIVMALLCG CDYCPDGIGG IGKDGVLKLF
250 260 270 280 290 300
NKYKESEILD RLRNWRAETD KYNALEMRVD DKSICSNCGH IGRTQSHTKS GCSVCRTKRG
310 320 330 340 350 360
CDKTLWKEQR LSIKAELILR RKALLAPEFP NEEIISEFLS EPPTIPNLNL GWRQPNLVKF
370 380 390 400 410 420
IKQIGHLLQW PEIYCFQKFF PILTRWQVQQ AARTNAIGRV ELVQPVDIIK KRTVKGVASL
430 440 450 460 470 480
ELRWQDPSGS FQGLIPDKQI SEFELEHPKG IEELYYTVEP LDMLEAAYPD LVASFLKSKE
490 500 510 520 530 540
KPPKKATRKK KTDPLSAIEN IPETLDKQKA NPAKPKRVVK KKKAPTEQAQ PSLQQFLRRE
550 560 570 580 590 600
KIGGTPVKDS LPQMAQLPQQ CSTPITKFLP SDLESDCDAV EFDMSDVVNG IISNPNARPT
610 620 630 640 650 660
VTRHEGRQLH YEALSDDLSM RLAQLSLRKD ELQEEPLPPV AEHKRDLSLV EHLPQSKRLS
670 680 690 700 710 720
LDDSFDLLVK GDLKKVPHLI QPIRTPVDRF KHQHRISEHL PQPAVEPAAN VSYFFNQSSD
730 740 750
NADAFEQLMN SSLGIQEQAE EDEEEEDDLV VISD