Q298L5

PR
Gene name
Miro (GA18862)
Protein name
Mitochondrial Rho GTPase
Names
Miro
Species
Drosophila pseudoobscura pseudoobscura (Fruit fly)
KEGG Pathway
dpo:Dpse_GA18862
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

165-239 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q298L5

Entry ID Method Resolution Chain Position Source
AF-Q298L5-F1 Predicted AlphaFoldDB

No variants for Q298L5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q298L5

No associated diseases with Q298L5

6 regional properties for Q298L5

Type Name Position InterPro Accession
domain EF-hand domain 328 - 363 IPR002048
domain Mitochondrial Rho GTPase 1/3, EF hand associated, type-1 368 - 438 IPR013566
domain EF hand associated, type-2 243 - 329 IPR013567
binding_site EF-Hand 1, calcium-binding site 221 - 233 IPR018247
domain MIRO domain 9 - 192 IPR020860-1
domain MIRO domain 441 - 604 IPR020860-2

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass type IV membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of mitochondrial outer membrane The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

4 GO annotations of biological process

Name Definition
cellular homeostasis Any process involved in the maintenance of an internal steady state at the level of the cell.
mitochondrial outer membrane permeabilization The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
mitochondrion transport along microtubule The directed movement of a mitochondrion along a microtubule, mediated by motor proteins.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGQYTVSTRK NVRILLVGDA GVGKTSLILS LVSEEYPEEV PPRAEEITIP ANVTPEQVPT
70 80 90 100 110 120
SIVDFSSVEQ TEETLGLEIN KAHVVCIVYS VDDDDSLDRI TSHWLPLIRS KCNATLEGDA
130 140 150 160 170 180
ETEAETEAAG EGLRKPIVLV GNKIDLIDYS TMDSVLAIME DFPEIESCVE CSAKTLHNIS
190 200 210 220 230 240
EMFYYAQKAV LHPTSPLYIM EDQELTPACK KSLVRIFKIC DTDGDNLLND YELNLFQRRC
250 260 270 280 290 300
FNTPLQPQIL DEVKAVIQKN VPDGIYNDAV TLKGFLFLHC LFIQRGRNET TWAVLRRFGY
310 320 330 340 350 360
NDQLEMCQEY LRPPLKIPPG SSTELSHRGQ KFLISVFERY DRDCDGALSP EEHKMLFSVC
370 380 390 400 410 420
PSSPWSYSTD IRKSCPINDK GWVTLHGWLC RWTLMTLIDV VKTMEYLAYL GFNVHENDSL
430 440 450 460 470 480
LAAIHVTRER RIDLAKRQSS RSVYKCHVIG PNGSGKTGLC RGFLVDEMQK LIGKEFKTNV
490 500 510 520 530 540
VHCINSVQVY GQEKHLILRD IDVRHALDPL QPQEVNCDVA CLVYDSSNPR SFEYVARIYI
550 560 570 580 590 600
KYYAESKIPV MIVGTKCDMD ERRQDYLMQP AEFCAKYKLL PPHLFSLRTN KKELYTKLAT
610 620 630 640
MAAFPHLRHF GLLTEDSKLL WKAGLGLAAA TMLGFIVLKT LSAAGSHSR