Q28VY6

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Jannaschia sp (strain CCS1)
KEGG Pathway
jan:Jann_0209
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

782-868 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28VY6

Entry ID Method Resolution Chain Position Source
AF-Q28VY6-F1 Predicted AlphaFoldDB

No variants for Q28VY6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28VY6

No associated diseases with Q28VY6

5 regional properties for Q28VY6

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 623 - 813 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 6 - 123 IPR007695
domain DNA mismatch repair protein MutS, core 274 - 602 IPR007696
domain DNA mismatch repair protein MutS, connector domain 132 - 257 IPR007860
domain DNA mismatch repair protein MutS, clamp 434 - 527 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNAQVTPMMA QYLEIKAAHP DALLFYRMGD FYEMFFDDAV AAAEALDIAL TKRGKHNGED
70 80 90 100 110 120
IAMCGVPAHS AESYLLTLIR KGFRVGICEQ MEDPATAKKR GGSKAVVRRE VVRLVTPGTL
130 140 150 160 170 180
TEDTLLEARR HNYLASYADV RGEGALAWCD ISTGDFRVMR CPAVRLGPEL ARLSPKEVLV
190 200 210 220 230 240
SDGLDIARQD AIIELGAAVT PLSPGSFDSA SAEQRLAGLF SVSTLEGFGN FARAEVSAMG
250 260 270 280 290 300
ALIDYLELTQ KGALPLLRAP RQQSADRLLQ LDTATRRNLE LTQALSGGRA NSLLSVLDRT
310 320 330 340 350 360
QTAGGARLLQ RRLTGPSTDL DVIRARHESV SFFFSDTLIR DDLEAELRRI PDLDRALSRL
370 380 390 400 410 420
ALDRGGPRDL SAIRDGLSGA ARLSDKLKIV DLPPLLEGAV QDLQGHDELS ALLDEALVAE
430 440 450 460 470 480
PPVQLRDGGL IAPGYHAELD EARTLRDEGR SVIATMQADY VEATGVNALK IKHNNVLGYF
490 500 510 520 530 540
IETTATHAEK MLNPPLSERF IHRQTTANQV RFTTVELSEL ETKILNAGNR ALEIERVLFQ
550 560 570 580 590 600
SLRDAILNCQ DQIGQAARGL AELDLSAALA RRAREGDWTQ PEMTEDRAFM IEGARHPVVE
610 620 630 640 650 660
AALAKDGTSF VANDCDLSAE GGAAITLLTG PNMAGKSTYL RQNALLVIMA QTGSFVPAKC
670 680 690 700 710 720
AKIGLVSQVF SRVGASDDLA RGRSTFMVEM VETATILNQA DDRALVILDE IGRGTATYDG
730 740 750 760 770 780
LSIAWATLEH LHETNQCRAL FATHYHEMTS LASKLDGLTN ATVAVKEWEG EVIFLHEVRE
790 800 810 820 830 840
GAADRSYGVQ VAKLAGLPDA VIARAQVVLD ALEKGEREGG ERKAVIDDLP LFAMMPAPAP
850 860 870
APSAPSLVEE KLRAVHPDEM TAREALNLLY ELKAELS