Q28UX6

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Jannaschia sp (strain CCS1)
KEGG Pathway
jan:Jann_0569
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

169-244 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28UX6

Entry ID Method Resolution Chain Position Source
AF-Q28UX6-F1 Predicted AlphaFoldDB

No variants for Q28UX6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28UX6

No associated diseases with Q28UX6

7 regional properties for Q28UX6

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 347 - 401 IPR000722-1
domain RNA polymerase, alpha subunit 398 - 488 IPR000722-2
domain RNA polymerase, N-terminal 238 - 517 IPR006592
domain RNA polymerase Rpb1, domain 3 492 - 645 IPR007066
domain RNA polymerase Rpb1, domain 1 17 - 345 IPR007080
domain RNA polymerase Rpb1, domain 5 763 - 1310 IPR007081
domain RNA polymerase Rpb1, domain 4 674 - 760 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNQELTNNPF NPLTPPKAFD EIKVSLASPE RILSWSYGEI KKPETINYRT FKPERDGLFC
70 80 90 100 110 120
ARIFGPIKDY ECLCGKYKRM KYRGVVCEKC GVEVTLQKVR RERMGHIELA APVAHIWFLK
130 140 150 160 170 180
SLPSRIGLML DMTLRDLERI LYFENYVVIE PGLTDLTYGQ LMGEEEFMDA QDAYGADAFQ
190 200 210 220 230 240
ANIGAEAIRE MLSQIDLESE ANQLREDLKE ATGELKPKKI IKRLKIVESF LESGNRPEWM
250 260 270 280 290 300
VMTVVPVIPP ELRPLVPLDG GRFATSDLND LYRRVINRNN RLKRLIELRA PDIIIRNEKR
310 320 330 340 350 360
MLQESVDALF DNGRRGRVIT GANKRPLKSL SDMLKGKQGR FRQNLLGKRV DFSGRSVIVT
370 380 390 400 410 420
GPELKLHQCG LPKKMALELF KPFIYSRLEA KGLSSTVKQA KKLVEKERPE VWDILDEVIR
430 440 450 460 470 480
EHPVLLNRAP TLHRLGIQAF EPVLIEGKAI QLHPLVCSAF NADFDGDQMA VHVPLSLEAQ
490 500 510 520 530 540
LEARVLMMST NNVLSPANGA PIIVPSQDMI LGLYYVTLAR EGMKGEGMIF ADVDEVRHAL
550 560 570 580 590 600
DAGEIHLHSK ITARLPQIDE EGNEIMVRFD TTPGRVMLGA LLPLNAKAPF DLVNRLLRKK
610 620 630 640 650 660
EVQQVIDTVY RYCGQKESVI FCDQIMSMGF KEAFKAGISF GKDDMVIPDT KWTLVEDARD
670 680 690 700 710 720
QVEEFEQQYM DGLITQGEKY NKVIDAWSKV NDKVTDAMMG TISASKRDEN DAEMEPNSVY
730 740 750 760 770 780
MMAHSGARGS VTQMKQLGGM RGLMAKPNGE IIETPIISNF KEGLTVLEYF NSTHGARKGL
790 800 810 820 830 840
SDTALKTANS GYLTRRLVDV AQDCIVRMDD CGTENTIKAE AAVNDGEVVA SLAERILGRT
850 860 870 880 890 900
AGEDVFIPGT DEIIVAKGEL IDERKADAVE AAGVTTMQMR SPLTCEAEEG VCATCYGRDL
910 920 930 940 950 960
ARGTKVNTGE AVGIIAAQSI GEPGTQLTMR TFHIGGVAQG GQQSFQEVNV DGKVEFRNAN
970 980 990 1000 1010 1020
LLKNANGESV VMGRNMVLAI MDDQGSERAS FKLGYGTNVL VEDGKKVVRG DRLFEWDPYT
1030 1040 1050 1060 1070 1080
LPIIAEAAGT AKFVDLVSGI SIRDETDDAT GMTQKIVSDW RTAPKGNELK PEIIIAGEDG
1090 1100 1110 1120 1130 1140
EPMRNDQGNP VTYTMSVDAI LSIEEGQTVK AGDVIARIPR EGAKTKDITG GLPRVAELFE
1150 1160 1170 1180 1190 1200
ARRPKDHAII AEIDGYVKFG RDFKNKRRIG IVPADESLEP VEYMVPKGKH IPVAEGDFVQ
1210 1220 1230 1240 1250 1260
VGDYIMDGNP APHDILAVLG VEALADYMID EVQDVYRLQG VKINDKHIEV IVRQMLQKWE
1270 1280 1290 1300 1310 1320
IQDSGETTLL KGEHVDKAEF DSANAKAVRD GRRPAQGEPI LLGITKASLQ TRSFISAASF
1330 1340 1350 1360 1370 1380
QETTRVLTEA SVQGKKDRLV GLKENVIVGR LIPAGTGGAT QDVERIAKGR DQVVIDAAQA
1390 1400
EAEAAAALAA PVMEDAAPDT DAAE