Q28I85

PR
Gene name
poc1a (wdr51a)
Protein name
POC1 centriolar protein homolog A
Names
Pat-interacting protein 2, Pix2, xPix2, WD repeat-containing protein 51A
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:549362
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

320-408 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28I85

Entry ID Method Resolution Chain Position Source
AF-Q28I85-F1 Predicted AlphaFoldDB

No variants for Q28I85

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28I85

No associated diseases with Q28I85

7 regional properties for Q28I85

Type Name Position InterPro Accession
repeat WD40 repeat 7 - 88 IPR001680-1
repeat WD40 repeat 91 - 307 IPR001680-2
conserved_site WD40 repeat, conserved site 33 - 47 IPR019775-1
conserved_site WD40 repeat, conserved site 201 - 215 IPR019775-2
repeat G-protein beta WD-40 repeat 117 - 131 IPR020472-1
repeat G-protein beta WD-40 repeat 159 - 173 IPR020472-2
repeat G-protein beta WD-40 repeat 201 - 215 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Colocalizes with mitochondria in cortical germ plasm islands
  • The mitochondrial localization may be microtubule-dependent (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGQPEDPSL ERHFKGHRDT VTTVDFNPNT KQLASGSMDS CLMIWNMKPQ MRAYRFVGHK
70 80 90 100 110 120
DAILSVDFSP SGHLIASASR DKTVRLWVPS VKGESTVFKA HTGTVRSVSF SGDGQSLVTA
130 140 150 160 170 180
SDDKTIKVWT VHRQKFLFSL NQHINWVRCA KFSPDGRLIV SASDDKTIKL WDKTSRECIH
190 200 210 220 230 240
SFCEHGGFVN FVDFHPSGTC IAAAATDNTV KVWDIRMNKL IQHYQVHSGV VNSLSFHPSG
250 260 270 280 290 300
NYLITASNDS TLKVLDLLEG RLLYTLHGHQ GPVTSVKFSR EGEFFASGGS DEQVMVWKTN
310 320 330 340 350 360
FDSASYADLL KYRQHDQFLN GGDYTSGVPA ADRHRPERNA QTDQADDLEP RHIQMSAKDR
370 380 390 400 410 420
SSPLSYTSRS IDQHHPQAED GNLRTVASTL EHIVGQLDIL TRTVGILEQR LSLTEDKLKE
430 440
CIDNQQATVS LSHSATKTPS F