Q28F51
Gene name |
tardbp (tdp43, TGas087d21.1) |
Protein name |
TAR DNA-binding protein 43 |
Names |
TDP-43 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:394651 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q28F51
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q28F51-F1 | Predicted | AlphaFoldDB |
No variants for Q28F51
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q28F51 | |||||
No associated diseases with Q28F51
1 regional properties for Q28F51
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Death effector domain | 24 - 107 | IPR001875 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic stress granule | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| regulation of circadian rhythm | Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| regulation of protein stability | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. |
| rhythmic process | Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEMEYIRVAE | DENEEPMEIP | SEDDGTVLLS | TVTAQFPGAC | GLRYRNPVNQ | CMRGVRLVEG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILHAPENGWG | NLVYVVNYPK | DNKRKMDETD | ASSAVKIKRA | VTKTSDLIVL | GLPWKTTEQD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKDYFSTFGE | VIMVQVKKDA | KTGHSKGFGF | VRFADYETQV | KVMSQRHMID | GRWCDCKLPN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SKSPDEPMRS | RKVFVGRCTE | DMSAEELRQF | FSQYGEVVDV | FIPKPFRAFA | FVTFADDQVA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QSLCGEDLII | KGVSVHVSTA | EPKHNNNRQL | ERGGRFPGPS | FGNQGYPNSR | PSSGALGNNQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GGNMGGGGGM | NFGAFSINPA | MMAAAQAALQ | SSWGMMGMLA | SQQNQSGPQG | SNQGQGNQQR |
| 370 | 380 | 390 | 400 | ||
| DQPQSFGSNN | SYGSNSGAIG | WGSPNAGSGS | GFNGGFSSSM | ESKSSGWGM |