Q28DL4
Gene name |
traf6 (TNeu045k15.1) |
Protein name |
TNF receptor-associated factor 6 |
Names |
EC 2.3.2.27 , E3 ubiquitin-protein ligase TRAF6 , RING-type E3 ubiquitin transferase TRAF6 |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
xtr:493524 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
72-275 (RZ domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q28DL4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q28DL4-F1 | Predicted | AlphaFoldDB |
No variants for Q28DL4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q28DL4 | |||||
No associated diseases with Q28DL4
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| tumor necrosis factor receptor binding | Binding to a tumor necrosis factor receptor. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| zinc ion binding | Binding to a zinc ion (Zn). |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| lipopolysaccharide-mediated signaling pathway | The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. |
| protein K63-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
| regulation of canonical NF-kappaB signal transduction | Any process that modulates I-kappaB kinase/NF-kappaB signaling. |
| tumor necrosis factor-mediated signaling pathway | The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZCC3 | TRAF6 | TNF receptor-associated factor 6 | Bos taurus (Bovine) | SS |
| Q9Y4K3 | TRAF6 | TNF receptor-associated factor 6 | Homo sapiens (Human) | EV |
| P70196 | Traf6 | TNF receptor-associated factor 6 | Mus musculus (Mouse) | SS |
| A7XUJ6 | TRAF6 | TNF receptor-associated factor 6 | Sus scrofa (Pig) | SS |
| B5DF45 | Traf6 | TNF receptor-associated factor 6 | Rattus norvegicus (Rat) | SS |
| B6CJY5 | TRAF6 | TNF receptor-associated factor 6 | Macaca mulatta (Rhesus macaque) | SS |
| Q6IWL4 | traf6 | TNF receptor-associated factor 6 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKERRASQKL | SSKSIMDPNQ | NVKCKIVVVG | DSQCGRTALL | HVFAKDCFPE | NYVPTVFENY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TASFEIDTQR | IELSLWDTSG | SPYYDNVRPL | SYPDSDAVLI | CFDISRPETL | DSVLKKWKGE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQEFCPNTKM | LLVGCKSDLR | TDVSTLVELS | NHRQTPVSYD | QGANMAKQIG | AATYIECSAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QSENSVRDIF | HVATLACVNK | TNKNVKRNKS | QRATKRISHM | PSRPELSAVA | TDLRKDKAKS |
| CTVM |