Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q28758
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q28758-F1 | Predicted | AlphaFoldDB |
1 variants for Q28758
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 80 | K>E | isoform E [UniProt] | No |
No associated diseases with Q28758
1 regional properties for Q28758
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 74 - 332 | IPR017452 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chylomicron | A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. |
| high-density lipoprotein particle | A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipid binding | Binding to a lipid. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| lipoprotein metabolic process | The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| GARAEVSADQ | VATVMWDYFS | QLSSNAKEAV | EHLQKSELTQ | QLNALFQDKL | GEVNTYAGDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QKKLVPFATE | LHERLAKDSK | KLKEEIRKEL | EEVRARLLPH | ANEVSQKIGE | NVRELQQRLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PYTDQLRTQV | NTQTEQLRRQ | LTPYAQRMER | VLRENADSLQ | TSLRPHADQL | KAKIDQNVEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKGRLTPYAD | EFKVKIDQTV | EELRRSLAPY | AQDAQEKLNH | QLEGLAFQMK | KNAEELKARI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SASAEELRQR | LAPLAEDMRG | NLRGNTEGLQ | KSLAELGGHL | DRHVEEFRLR | VEPYGENFNK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ALVQQMEQLR | QKLGPHAGDV | EGHLSFLEKD | LRDKVNSFFS | TFKEKESQDN | TLSLPEPEQQ |
| 370 | 380 | 390 | 400 | ||
| QEQQQEQEQQ | QEQQEEQQQQ | EQQQEQEQQQ | EQVQMLAPLE | S |