Q28689

PR
Gene name
ABCC2
Protein name
ATP-binding cassette sub-family C member 2
Names
Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, Epithelial basolateral chloride conductance regulator, Multidrug resistance-associated protein 2
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
EC number
7.6.2.2: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

838-973 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28689

Entry ID Method Resolution Chain Position Source
AF-Q28689-F1 Predicted AlphaFoldDB

No variants for Q28689

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28689

No associated diseases with Q28689

7 regional properties for Q28689

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 635 - 859 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1298 - 1532 IPR003439-2
domain AAA+ ATPase domain 661 - 836 IPR003593-1
domain AAA+ ATPase domain 1324 - 1509 IPR003593-2
domain ABC transporter type 1, transmembrane domain 322 - 603 IPR011527-1
domain ABC transporter type 1, transmembrane domain 978 - 1262 IPR011527-2
conserved_site ABC transporter-like, conserved site 759 - 773 IPR017871

Functions

Description
EC Number 7.6.2.2 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
ABC-type glutathione S-conjugate transporter activity Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out).
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
organic anion transmembrane transporter activity Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.

2 GO annotations of biological process

Name Definition
bile acid and bile salt transport The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
leukotriene transport The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLDKFCNSTF WNSSLLDSPE ADLPLCFEQT VLVWIPLIFL WLLAPWQLFH VYRSRTKRSP
70 80 90 100 110 120
ITKFYLAKQV LVGCLLILAV IELILVLTEN SGQATIPAVR YTNPILYLVT WLLVLLIQHS
130 140 150 160 170 180
RQSCVQKNSW FLSLFWILSI LCGTFQFQTL IRTLLRDSNS NLAYSCLFFI SYGFQILILI
190 200 210 220 230 240
LSAFSEKDNS SKNPSVTASF LSKISFSWYD SVVLKGYKRP LTLEDVWDID EEFKAKTIVS
250 260 270 280 290 300
RFEVHMAKEL KKARKAFQKR QQKKSQKNSR LQGLNKNQSQ SQDVLVLEET KKKNKKSGTT
310 320 330 340 350 360
KDFPKSWLVK TIFKTFYMVL LKSFLLKLVY DLLTFLNPQL LKLLITFVSD PNSYAWLGYI
370 380 390 400 410 420
FAILLFAVAL IQSICLQTYF HMCFNLGMCV GTTVMATVYK KALTISNLAK RQYTIGETVN
430 440 450 460 470 480
LMSVDAQKLM DVTNFIHLVW SSVLQIVLSI YFLWVELGPS VLAGVGVMVL LIPVNGILAT
490 500 510 520 530 540
KNRNIQFKNM KYKDKRLRIM NEILSGMKIL KYFAWEPSFK DQVHNLRKKE LKNLRTFAYM
550 560 570 580 590 600
QSVVMFLLYL TPVLVSVTTF SVYVLVDSNN ILDAEKAFTS ITLFNILRFP MSMLPNVISA
610 620 630 640 650 660
MLQASVSVDR LEKYLSGDDL DTSAIQRDPN FDKAVQFSEA SFTWDRNLEP TIRNVNLDIM
670 680 690 700 710 720
PGQLVAVVGT VGSGKSSLMS AMLGEMENVH GHITIKGTTA YVPQQSWIQN GTIKDNILFG
730 740 750 760 770 780
AEFDERRYQR VLEACALLPD LEILPGGDLA EIGEKGINLS GGQKQRISLA RASYQNSDIY
790 800 810 820 830 840
ILDDPLSAVD AHVGKHIFNK VLGPNGLLNG KTRLLVTHSL HFLPQVDEIV VVENGTILEK
850 860 870 880 890 900
GSYSSLLAKK GVFAKNLKMF VKHTDSEGEV TVNDGSEEDD DDDSGLISSI EEFPEDSISL
910 920 930 940 950 960
TLKRENSLHR TLSRSSRSSG RRLKSLKNSL KAQNGKTPKE EEVVKGQKLI KKEFMETGKV
970 980 990 1000 1010 1020
KFSIYLKYLQ AIGWCSIVGI IFAYVLNSVA FIGSNLWLSA WTSDSNTYNG TNYPASQRDL
1030 1040 1050 1060 1070 1080
RIGIFGVLGL AQGLTVLVAS FWSASGCAHA SNILHKQLLN NILRAPMSFF NTTPIGRIVN
1090 1100 1110 1120 1130 1140
RFAGDISTVD DTLPQSLRSW MMCFLAIIST LIMICMATPV FAVIIIPLAI IYVAVQVFYV
1150 1160 1170 1180 1190 1200
ATSRQLRRLD SVTRSPIYSH FTETVSGLPV IRAFEHQQRF LKQNEIGIDT NQKCVSSWIT
1210 1220 1230 1240 1250 1260
SNRWLAFRLE LVGNLVVFSS ALMMVIYRDT LSGDVVGFVL SNALNITQTL NWLVRMTSET
1270 1280 1290 1300 1310 1320
ETNIVAVERI TEYIKVENEA PWVTDKRPPA GWPHKGEIQF SNYQVRYRPE LDLVLKGINC
1330 1340 1350 1360 1370 1380
DIKSMEKIGV VGRTGAGKSS LTNCLFRILE AAGGHITIDG IDIASIGLHD LRGKLTIIPQ
1390 1400 1410 1420 1430 1440
DPVLFSGSLR MNLDPFNNYS DEEIWRALEL AHLKSFVAGL QHGLSREVSE AEDNLSIGQR
1450 1460 1470 1480 1490 1500
QLLCLGRALL RKSKILVLDE ATAAVDLETD HLIQTTIRNE FSHCTVITIA HRLHTIMDSD
1510 1520 1530 1540 1550 1560
KIMVLDNGNI VEYGSPEELL ESAGPFSLMA KESGIENVNN TAFWAAAARD AGAGRLSPGF
ASVT