Q28647

PR
Gene name
PPP2R5B
Protein name
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
Names
PP2A B subunit isoform B'-alpha, PP2A B subunit isoform B'-beta, PP2A B subunit isoform B56-beta, PP2A B subunit isoform PR61-beta, PP2A B subunit isoform R5-beta
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009215
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-99 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28647

Entry ID Method Resolution Chain Position Source
AF-Q28647-F1 Predicted AlphaFoldDB

No variants for Q28647

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28647

No associated diseases with Q28647

No regional properties for Q28647

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q28647

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.

1 GO annotations of molecular function

Name Definition
protein phosphatase regulator activity Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

1 GO annotations of biological process

Name Definition
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
METKLPPAST PTSPSSPGLS PVPPADKVDG FSRRSLRRAR PRRSHSSSQF RYQSNQQELT
70 80 90 100 110 120
PLPLLKDVPA SELHDLLSRK LAQCGVMFDF LDCVADLKGK EVKRAALNEL VECVGSTRGV
130 140 150 160 170 180
LIEPVYPDII RMISVNIFRT LPPSENPEFD PEEDEPNLEP SWPHLQLVYE FFLRFLESPD
190 200 210 220 230 240
FQPSVAKRYV DQKFVLMLLE LFDSEDPRER EYLKTILHRV YGKFLGLRAY IRKQCNHIFL
250 260 270 280 290 300
RFIYEFEHFN GVAELLEILG SIINGFALPL KTEHKQFLVR VLIPLHSVKS LSVFHAQLAY
310 320 330 340 350 360
CVVQFLEKDA TLTEHVIRGL LKYWPKTCTQ KEVMFLGEVE EILDVIEPSQ FVKIQEPLFK
370 380 390 400 410 420
QVARCVSSPH FQVAERALYF WNNEYILSLI EDNCHTVLPA VFGTLYQVSK EHWNQTIVSL
430 440 450 460 470 480
IYNVLKTFME MNGKLFDELT ASYKLEKQQE QQKARERQEL WQGLEELRLR RLQGTQGTQG
490
AREAPLQRFV PQVAATGGQS