Q28558
Gene name |
GPR50 |
Protein name |
Melatonin-related receptor |
Names |
G protein-coupled receptor 50, H9 |
Species |
Ovis aries (Sheep) |
KEGG Pathway |
oas:443023 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q28558
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q28558-F1 | Predicted | AlphaFoldDB |
No variants for Q28558
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q28558 | |||||
No associated diseases with Q28558
1 regional properties for Q28558
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 45 - 294 | IPR017452 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| melatonin receptor activity | Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGRTLAVPTP | YGCIGCKLPQ | PDYPPALIVF | MFCAMVITIV | VDLIGNSMVI | LAVSKNKKLR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NSGNVFVVSL | SVADMLVAIY | PYPLMLHAMA | IGGWDLSKLQ | CQMVGFITGL | SVVGSIFNIM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AIAINRYCYI | CHSLQYERIF | SVRNTCIYLA | VTWIMTVLAV | LPNMYIGTIE | YDPRTYTCIF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NYVNNPAFAV | TIVCIHFVLP | LLIVGFCYVK | IWTKVLAARD | PAGQNPDNQL | AEVRNFLTMF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VIFLLFAVCW | CPINALTVLV | AVNPKEMAGK | IPNWVYLAAY | FIAYFNSCLN | AVIYGVLNEN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FRREYWTIFH | AMRHPVLFLS | GLLTDVREMQ | EAQAHTHARA | RARTQAHEQD | HAHACPAVEE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IPMSVRNVPL | PGHGAAGQPE | CVSGHPKPAS | GHSRSVSARR | KSASAHPKSA | SGQSKSATVY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PKPTSVHFKP | SSVYFKADSV | YFKPSSSHPK | PITGPSKTAI | SPATSFPKPT | TGYTQHATIH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SEPTTLDYLE | PITTSHSKPV | IASHSELAAS | CHLECNIFDL | SDPTSSPASD | SSNSAASLLD |
| 550 | 560 | 570 | |||
| PTAAAAATVN | PTVVTTDYHE | IVLIDVDADS | DEMAV |