Q28527

PR
Gene name
KCNA4
Protein name
Potassium voltage-gated channel subfamily A member 4
Names
FK1, Voltage-gated potassium channel subunit Kv1.4
Species
Mustela putorius furo (European domestic ferret) (Mustela furo)
KEGG Pathway
mpuf:101689037
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-200 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28527

Entry ID Method Resolution Chain Position Source
AF-Q28527-F1 Predicted AlphaFoldDB

No variants for Q28527

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28527

No associated diseases with Q28527

4 regional properties for Q28527

Type Name Position InterPro Accession
domain BTB/POZ domain 177 - 277 IPR000210
domain Potassium channel tetramerisation-type BTB domain 179 - 267 IPR003131
domain Ion transport domain 311 - 571 IPR005821
domain Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain 1 - 73 IPR012897

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Cell projection, axon
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axon initial segment Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

2 GO annotations of molecular function

Name Definition
potassium ion binding Binding to a potassium ion (K+).
voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

3 GO annotations of biological process

Name Definition
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEVAMVSAES SGCNSHMPYG YAAQARARER ERLAHSRAAA AAAVAAATAA VEGSGGSGGG
70 80 90 100 110 120
SHHHHQSRGA CTSHDPQGGR GSRRRRRQRP EKKKAHHRQS SFPHCSDLMP SGSEEKILRE
130 140 150 160 170 180
LSEEEEEEED EEEEEEEGRF YYSEDDHGDE CSYTDLLPQD DGGGGGYSSV RYSDCCERVV
190 200 210 220 230 240
INVSGLRFET QMKTLAQFPE TLLGDPEKRT QYFDPLRNEY FFDRNRPSFD AILYYYQSGG
250 260 270 280 290 300
RLKRPVNVPF DIFTEEVKFY QLGEEALLKF REDEGFVREE EDRALPENEF KKQIWLLFEY
310 320 330 340 350 360
PESSSPARGI AIVSVLVILI SIVIFCLETL PEFRDDRDLI MALSAGGHSG LLNDTSAPHL
370 380 390 400 410 420
ENSGHTIFND PFFIVETVCI VWFSFEFVVR CFACPSQALF FKNIMNIIDI VSILPYFITL
430 440 450 460 470 480
GTDLAQQQGG GNGQQQQAMS FAILRIIRLV RVFRIFKLSR HSKGLQILGH TLRASMRELG
490 500 510 520 530 540
LLIFFLFIGV ILFSSAVYFA EADEPTTHFQ SIPDAFWWAV VTMTTVGYGD MKPITVGGKI
550 560 570 580 590 600
VGSLCAIAGV LTIALPVPVI VSNFNYFYHR ETENEEQTQL TQNAVSCPYL PSNLLKKFRS
610 620 630 640 650
STSSSLGDKS EYLEMEEGVK ESLCAKEGKC QGKGDDSETD KNNCSNAKAV ETDV