Q28256
Gene name |
GP1BA |
Protein name |
Platelet glycoprotein Ib alpha chain |
Names |
|
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:403638 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q28256
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q28256-F1 | Predicted | AlphaFoldDB |
No variants for Q28256
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q28256 | |||||
No associated diseases with Q28256
No regional properties for Q28256
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q28256 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchored component of external side of plasma membrane | The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
| glycoprotein Ib-IX-V complex | A transmembrane signalling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| blood coagulation, intrinsic pathway | A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| fibrinolysis | A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. |
| positive regulation of platelet activation | Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. |
| release of sequestered calcium ion into cytosol | The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHLLLWLLLL | ARLCRPEFIC | EVSKVTSQVE | VNCDNKGLKA | LPPGLPGDTA | ILHLAENPLG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AFSTALLGPL | TRLAQLHLRQ | SQLTQLQVDG | MLPRLETLDV | SHNRLKSLPS | LGRALPALTT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDASFNELVA | LSPGTLDGLS | HLHELYLRGN | KLKTLPPRLL | APTAQLRKLN | LADNRLTELP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PGFLEGLGEL | DTLYLQGNWL | RTVPKGFFGD | LLLPFTFLHG | NPWSCDCEIL | YLARWLRDNS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NNVYLWKEGV | EAKATTPNVD | SVRCVNWKNV | PVHTYQGKDC | PSPMDGGDMD | YDNYDDEDEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LPGVEAPATR | AVVSFSTHTK | AHTTHWGLLY | PTFAYPDHQM | AYLSSTLELT | EKQTMFPSTL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GPIMPTTTPE | PTTPPTTLEP | TTTPTTPEPT | TPPTTLEPTT | TPITPEPTMP | PTTLEPTTTP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ITPEPTTPST | TPTTPQPATT | PTTPQPATTP | TTPQPATTPT | TPQPTTTPTI | PELPTPPTTP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EPTMPPTTLE | PTTTPTSPTT | TLILSESNTF | LGIPELTSPC | TTSEYPIVPS | LVHLPEAHEV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ARGTSDSSRN | HRLFNPDLCC | LLPLGFYILG | LLWLLFASVV | LILLLTWAQH | VKPQALAMAT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YTTHLELQWG | KQVTVPWAWL | LFLQGSFPTF | RSSLFLWVRA | NSYVGPLMAG | RRPSALSLGR |
| 670 | |||||
| GQDLLGTVGV | RYSSHSL |