Q28065

PR
Gene name
C4BPA
Protein name
C4b-binding protein alpha chain
Names
C4bp
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281651
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

501-573 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28065

Entry ID Method Resolution Chain Position Source
AF-Q28065-F1 Predicted AlphaFoldDB

30 variants for Q28065

Variant ID(s) Position Change Description Diseaes Association Provenance
rs440885506 21 P>R No EVA
rs457788535 34 F>L No EVA
rs455045653 48 G>C No EVA
rs457750915 72 T>A No EVA
rs457750915 72 T>S No EVA
rs478006144 113 E>* No EVA
rs451351440 143 Y>S No EVA
rs471415426 144 V>G No EVA
rs466853057 146 I>F No EVA
rs463226037 147 G>R No EVA
rs442239593 149 A>P No EVA
rs478948261 150 N>I No EVA
rs447575849 159 G>V No EVA
rs470070339 205 R>C No EVA
rs435369850 218 R>I No EVA
rs449139082 224 I>R No EVA
rs472048946 300 L>H No EVA
rs451839913 300 L>V No EVA
rs437248916 301 G>R No EVA
rs457447284 301 G>V No EVA
rs440023574 367 C>W No EVA
rs442204008 369 E>K No EVA
rs460082448 395 G>V No EVA
rs42905463 459 K>E No EVA
rs207815234 489 K>R No EVA
rs438085706 494 Y>H No EVA
rs454945615 509 I>R No EVA
rs800016415 520 V>L No EVA
rs440701218 521 V>D No EVA
rs799341637 599 R>K No EVA

No associated diseases with Q28065

28 regional properties for Q28065

Type Name Position InterPro Accession
domain K Homology domain 149 - 217 IPR004087-1
domain K Homology domain 221 - 289 IPR004087-2
domain K Homology domain 294 - 362 IPR004087-3
domain K Homology domain 363 - 429 IPR004087-4
domain K Homology domain 434 - 502 IPR004087-5
domain K Homology domain 506 - 575 IPR004087-6
domain K Homology domain 580 - 648 IPR004087-7
domain K Homology domain 652 - 721 IPR004087-8
domain K Homology domain 726 - 795 IPR004087-9
domain K Homology domain 799 - 868 IPR004087-10
domain K Homology domain 872 - 972 IPR004087-11
domain K Homology domain 973 - 1039 IPR004087-12
domain K Homology domain 1051 - 1122 IPR004087-13
domain K Homology domain 1126 - 1195 IPR004087-14
domain K Homology domain, type 1 154 - 212 IPR004088-1
domain K Homology domain, type 1 225 - 285 IPR004088-2
domain K Homology domain, type 1 298 - 357 IPR004088-3
domain K Homology domain, type 1 369 - 425 IPR004088-4
domain K Homology domain, type 1 438 - 498 IPR004088-5
domain K Homology domain, type 1 512 - 571 IPR004088-6
domain K Homology domain, type 1 584 - 644 IPR004088-7
domain K Homology domain, type 1 656 - 717 IPR004088-8
domain K Homology domain, type 1 732 - 791 IPR004088-9
domain K Homology domain, type 1 804 - 865 IPR004088-10
domain K Homology domain, type 1 877 - 968 IPR004088-11
domain K Homology domain, type 1 974 - 1034 IPR004088-12
domain K Homology domain, type 1 1056 - 1118 IPR004088-13
domain K Homology domain, type 1 1131 - 1191 IPR004088-14

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
complement activation, classical pathway Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of complement activation, classical pathway Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q09101 hig Locomotion-related protein Hikaru genki Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MKHQRVPVMI LHSKGTMASW PFSRLWSISD PILFQVTLVA TLLATVLGSC GIPPYLDFAF
70 80 90 100 110 120
PINELNETRF ETGTTLRYTC RPGYRISSRK NFLICDGTDN WKYKEFCVKK RCENPGELLN
130 140 150 160 170 180
GQVIVKTDYS FGSEIEFSCS EGYVLIGSAN SYCQLQDKGV VWSDPLPQCI IAKCEPPPTI
190 200 210 220 230 240
SNGRHNGGDE DFYTYGSSVT YSCDRDFSML GKASISCRVE NKTIGVWSPS PPSCKKVICV
250 260 270 280 290 300
QPVVKDGKIT SGFGPIYTYQ QSIVYACNKG FRLEGDSLIH CEADNSWNPP PPTCELNGCL
310 320 330 340 350 360
GLPHIPHALW ERYDHQTQTE QQVYDIGFVL SYKCHFGYKP ETDGPTTVTC QSNLEWSPYI
370 380 390 400 410 420
ECKEVCCPEP NLNNYGSITL HRRPSTSTHC TYISGDKISY ECHSKYMFDA LCTKHGTWSP
430 440 450 460 470 480
RTPECRPDCK SPPVIAHGQH KVVSKFFTFD HQAVYECDKG YILVGAKELS CTSSGWSPAV
490 500 510 520 530 540
PQCKALCLKP EIEYGRLSVE KVRYVEPEII TIQCESGYSV VGSENITCSE DRTWYPEVPK
550 560 570 580 590 600
CEWEYPEGCE QVVTGRKLLQ CLSRPEEVKL ALEVYKLSLE IEILQTNKLK KEAFLLRERE
KNVTCDFNPE