Q26619
Gene name |
|
Protein name |
cAMP-dependent protein kinase type II regulatory subunit |
Names |
|
Species |
Strongylocentrotus purpuratus (Purple sea urchin) |
KEGG Pathway |
spu:373288 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q26619
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q26619-F1 | Predicted | AlphaFoldDB |
No variants for Q26619
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q26619 | |||||
No associated diseases with Q26619
6 regional properties for Q26619
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 121 - 237 | IPR000595-1 |
| domain | Cyclic nucleotide-binding domain | 239 - 363 | IPR000595-2 |
| domain | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | 7 - 44 | IPR003117 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 148 - 164 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 184 - 201 | IPR018488-2 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 311 - 328 | IPR018488-3 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cAMP-dependent protein kinase complex | An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| cAMP-dependent protein kinase inhibitor activity | Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase. |
| protein kinase A catalytic subunit binding | Binding to one or both of the catalytic subunits of protein kinase A. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of cAMP-dependent protein kinase activity | Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNFEIPEGLT | DLLQDFTVAV | LREKPSDLVE | FASSYFAKLQ | ENNISLGGKR | GVTFTAPEDA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ESDIDDEPPE | LPKNRYARRK | SVCAEKYDPE | ADNDTDTQKL | VYPKSDEQRA | RLTEAVKNIL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LFRALDEKQM | QEVIDAMFEK | KTTPGDHVID | QGDDGDNFYV | IDRGEYDIFV | NDNKVGAYKD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SGSFGELALM | YNTPRAATIA | ATTDGILWAL | DRVSFRRIVL | KNAAKKRRIY | EELLEKVSIF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSLEPYERMN | LADALVTRTY | EDGDCIIAQG | DGADGCYFIE | AGQCRIAMKS | ERSDNPDEEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EVAIYNQGQY | FGELALLTNK | PRAASVYAVE | DVDCLLDVNA | FERLLGPCMD | IMKRNIEHYE |
| QETSRLFGK |