Q26614

PR
Gene name
FGFR
Protein name
Fibroblast growth factor receptor
Names
SpFGFR
Species
Strongylocentrotus purpuratus (Purple sea urchin)
KEGG Pathway
spu:373310
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

110-330 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

798-823 (Activation loop from InterPro)

Target domain

639-925 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q26614

Entry ID Method Resolution Chain Position Source
AF-Q26614-F1 Predicted AlphaFoldDB

No variants for Q26614

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q26614

No associated diseases with Q26614

16 regional properties for Q26614

Type Name Position InterPro Accession
domain Protein kinase domain 639 - 925 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 639 - 912 IPR001245
domain Immunoglobulin subtype 2 167 - 233 IPR003598-1
domain Immunoglobulin subtype 2 297 - 365 IPR003598-2
domain Immunoglobulin subtype 2 394 - 508 IPR003598-3
domain Immunoglobulin subtype 161 - 245 IPR003599-1
domain Immunoglobulin subtype 291 - 376 IPR003599-2
domain Immunoglobulin subtype 388 - 519 IPR003599-3
domain Fibronectin type III 55 - 152 IPR003961
domain Immunoglobulin-like domain 150 - 230 IPR007110-1
domain Immunoglobulin-like domain 282 - 374 IPR007110-2
domain Immunoglobulin-like domain 383 - 505 IPR007110-3
active_site Tyrosine-protein kinase, active site 777 - 789 IPR008266
domain Immunoglobulin I-set 299 - 375 IPR013098
binding_site Protein kinase, ATP binding site 645 - 673 IPR017441
domain Tyrosine-protein kinase, catalytic domain 639 - 912 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor binding Binding to a fibroblast growth factor.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

2 GO annotations of biological process

Name Definition
positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLPRCPRTR TVMFSRTLTR CYPQRTLWIA ILCVICSWTL STAGATTIRD KEVKPDAPQD
70 80 90 100 110 120
LTAIPVKAEA IVLTWKKPLK GQTDGYIVVY CLKRNKGNGC ERQKIEGGNV TEVEVTNLYA
130 140 150 160 170 180
NHTYQFQVQS WYSDHPKGAS TGYIEASGTP PIPPTLRRNF KGLVEKSLGF EHKIPCPVKA
190 200 210 220 230 240
DPRPYTRWLK NGTDLTPNDP DDNVSFTKTS IVFKRLRFSD AGLYTCVASN FFGQPIHVNF
250 260 270 280 290 300
TLIVVDTHSE SYAESSVLES FSSLELETGP YNETEEEETH FPRFTDTERM EPEKPLPSNT
310 320 330 340 350 360
KVRLECGARG TPTPNITWIK DGVQKWKINV IRPTRVEEKG FVLIIRRAIV RDTGKYTCIV
370 380 390 400 410 420
SNQYGTIEHT YDVKIRERLP VKPIMSPMKN VTATVGSNTS FVCRVVNDLT PHFAWMRFNG
430 440 450 460 470 480
TNNTKQRLTD IDDHISILQQ RWVEEPMLTC DEFLDVFYQN QSKRMLECLH LIQLETQGGM
490 500 510 520 530 540
EEANQLKLYN VQYEDEGPYL CVAGNFYGMS WEGAYLDVVE PTTQAPVRTN PPAVYIPNNM
550 560 570 580 590 600
QPTSKTQLII FSVVGFVVVL ILVTCIAILC KQTQVRHRRP SDKPDISGPK HLYRQTSVDS
610 620 630 640 650 660
TQSIAPLFGG RNRLTSSLTV ISEYDIPLDP EWEFPRDRLT VGKTIGEGAF GKVVIGEAVG
670 680 690 700 710 720
IVCQEKTSTV AVKMLKANAM DREFSDLISE LAMMKMIGKN PNIINLLGCC TQEGPPYVIV
730 740 750 760 770 780
EFAHHGNLRD FLRSRRPPEE YEKSILLTTS QTLTNKDLMS MAYQVARGMD FLASKKCIHR
790 800 810 820 830 840
DLAARNVLVT EDFEMKICDF GLARDIHYID FYRKTTDGRL PVKWMAPEAL FDRMFTTQSD
850 860 870 880 890 900
VWSFGILLWE IMTLGGTPYP SVPVEQMFDY LRSGKRLEKP QNTSLEIYHI LCECWRTSPG
910 920 930 940 950 960
QRPTFCELVE DLDRIISVSS NQDYLDLEAV GDAPVKTFQE SERMAFMGFR APLSPQVYYK
970
VPQTRDCCPY AN