Q26228
Gene name |
ku70 |
Protein name |
ATP-dependent DNA helicase 2 subunit 1 |
Names |
ATP-dependent DNA helicase II 70 kDa subunit, ATP-dependent DNA helicase II subunit Ku70, Ku autoantigen protein p70 homolog |
Species |
Rhipicephalus appendiculatus (Brown ear tick) |
KEGG Pathway |
|
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q26228
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q26228-F1 | Predicted | AlphaFoldDB |
No variants for Q26228
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q26228 | |||||
No associated diseases with Q26228
5 regional properties for Q26228
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminoacyl-tRNA synthetase, class II (D/K/N) | 159 - 497 | IPR004364 |
| domain | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | 64 - 142 | IPR004365 |
| domain | Aminoacyl-tRNA synthetase, class II | 180 - 495 | IPR006195 |
| domain | Lysyl-tRNA synthetase, class II, C-terminal | 173 - 498 | IPR018149 |
| domain | Lysine-tRNA ligase, class II, N-terminal | 63 - 170 | IPR044136 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| Ku70:Ku80 complex | Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| damaged DNA binding | Binding to damaged DNA. |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| telomeric DNA binding | Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| double-strand break repair via nonhomologous end joining | The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. |
| telomere maintenance | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDQPWMRQDD | DESDDESSTV | DFGQAVDGIL | FLIDATEGMF | EEVDGDTAFM | QCIKAAKSTM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LNKITSSPKD | LVGIILFGTD | KDNNPNRFKN | VYVLQDLESP | GAESVLKLEK | LIADGPKKFK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QEYGHGNVNM | ADVLWTCALM | FSKSRAGQRR | VLVLTNQDDP | HKGSGDLDDK | AVVKAKDLLQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SGIELDLVHL | KPPGDKKFRP | QILYKNLVTD | KENYEDGFPE | ASDKMEELLL | RVRMKDHKKR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLMSLPFWLG | PEVKMSVSLY | NLVRPTGKPA | TTRLARDNNE | ELLSRRITYA | MDSAEALMPG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DISKTQEYGG | RKAYFDICEV | KQIKSMAPPG | LQLLGFKPLS | YLEKQPHVRP | SHFVYPDEGS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VRGSTRLFAA | LLQSCLRHRV | APICFWISRA | AQAPKLVYLL | AQEEERDPHG | LQMVPPGFHV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VQLPFSDDRR | RLQALQEGTT | KATPGLVALA | REMAEKLRFT | YHPDKFENPE | LQGFWSCLEA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LALDRDDAEH | PKDYTRPDHE | KMKAKAGEEM | DAFLEAAFPD | GCSATTAGSR | KRTQAGEGGQ |
| 550 | 560 | 570 | 580 | 590 | |
| AKKARSENQG | SNVDVREEAK | RGKLASLTVS | VLRDFCKQEG | LRCPSKKAEI | VDCIKKHLKL |