Q25604

PR
Gene name
nhr-1
Protein name
Nuclear hormone receptor-like 1
Names
Species
Onchocerca volvulus
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-59 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q25604

Entry ID Method Resolution Chain Position Source
AF-Q25604-F1 Predicted AlphaFoldDB

No variants for Q25604

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q25604

No associated diseases with Q25604

2 regional properties for Q25604

Type Name Position InterPro Accession
domain Nuclear hormone receptor, ligand-binding domain 145 - 367 IPR000536
domain Zinc finger, nuclear hormone receptor-type 32 - 107 IPR001628

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
zinc ion binding Binding to a zinc ion (Zn).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
METKESTMND QNTHTRSRNK AIPYLPRYMK PGQPCVVCGD DATGLHYRAI TCEGCKGFFR
70 80 90 100 110 120
RTVQQKIVYK CKSIERCEIS KISRNICQFC RFQKCLRNGM TKSLVLNETE RIAKRKMIID
130 140 150 160 170 180
NRERRKLEHL RTLLKASSLA DKQDEFQSRI DQVTANYCKI MDNSLEYKFK SNKKSERLIE
190 200 210 220 230 240
LTKLVSQQVR QFAETIEICD TLNPSEKEEI IAKSWLVVKI LQIIHEFNPT ECCLMLANNT
250 260 270 280 290 300
TYIPAKGNYS ELDKTTKIFE NLINLAISFN CMQLDNRQLA LLSALLIYNP ENVKRSKEKI
310 320 330 340 350 360
DKIHVELWKC LQSISEMHDD DSSDLLHWPN FLVRIPYLIL TVSKMQDFFQ DENNINAIAN
ILLFKFT