Q25519

PR
Gene name
ppo
Protein name
Phenoloxidase subunit 2
Names
proPO-p2
Species
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
KEGG Pathway
EC number
1.14.18.1: With another compound as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

528-602 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q25519

Entry ID Method Resolution Chain Position Source
3HHS X-ray 197 A A 2-695 PDB
AF-Q25519-F1 Predicted AlphaFoldDB

No variants for Q25519

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q25519

No associated diseases with Q25519

4 regional properties for Q25519

Type Name Position InterPro Accession
domain Hemocyanin/hexamerin middle domain 154 - 415 IPR000896
domain Tyrosinase copper-binding domain 401 - 412 IPR002227
domain Hemocyanin, C-terminal 427 - 680 IPR005203
domain Hemocyanin, N-terminal 26 - 144 IPR005204

Functions

Description
EC Number 1.14.18.1 With another compound as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
chloride ion binding Binding to a chloride ion (Cl-).
copper ion binding Binding to a copper (Cu) ion.
tyrosinase activity Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates.

3 GO annotations of biological process

Name Definition
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
melanin biosynthetic process from tyrosine The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.
positive regulation of melanization defense response Any process that increases the rate or extent of the melanization defense response during injury or invasion.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADIFDSFEL LYDRPGEPMI NTKGEDKVLF ELTEQFLTPE YANNGLELNN RFGDEEEVSR
70 80 90 100 110 120
KIILKNLDKI PEFPKAKQLP NDADFSLFLP SHQEMANEVI DVLMSVTENQ LQELLSTCVY
130 140 150 160 170 180
ARINLNPQLF NYCYTVAIMH RRDTGKVRVQ NYAEIFPAKF LDSQVFTQAR EAAAVIPKTI
190 200 210 220 230 240
PRTPIIIPRD YTATDLEEEH RLAYWREDLG INLHHWHWHL VYPFSASDEK IVAKDRRGEL
250 260 270 280 290 300
FFYMHQQIIA RYNCERLCNS LKRVKKFSDW REPIPEAYYP KLDSLTSARG WPPRQAGMRW
310 320 330 340 350 360
QDLKRPVDGL NVTIDDMERY RRNIEEAIAT GNVILPDKST KKLDIDMLGN MMEASVLSPN
370 380 390 400 410 420
RDLYGSIHNN MHSFSAYMHD PEHRYLESFG VIADEATTMR DPFFYRVHAW VDDIFQSFKE
430 440 450 460 470 480
APHNVRPYSR SQLENPGVQV TSVAVESAGG QQNVLNTFWM QSDVNLSKGL DFSDRGPVYA
490 500 510 520 530 540
RFTHLNHRPF RYVIKANNTA SARRTTVRIF IAPKTDERNL PWALSDQRKM FIEMDRFVVP
550 560 570 580 590 600
LSAGENTITR QSTESSLTIP FEQTFRDLSI QGSDPRRSEL AAFNYCGCGW PQHMLVPKGT
610 620 630 640 650 660
VGGVAYQLFV MLSNYELDKI EQPDGRELSC VEASMFCGLK DKKYPDARPM GYPFDRPSNS
670 680 690
ATNIEDFSAM SNMGLQDIVI KLSDVTEPNP RNPPA