Q25452

PR
Gene name
Protein name
Muscle calcium channel subunit alpha-1
Names
MDL-alpha-1
Species
Musca domestica (House fly)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

695-782 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q25452

Entry ID Method Resolution Chain Position Source
AF-Q25452-F1 Predicted AlphaFoldDB

No variants for Q25452

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q25452

No associated diseases with Q25452

1 regional properties for Q25452

Type Name Position InterPro Accession
conserved_site Di-trans-poly-cis-decaprenylcistransferase-like, conserved site 194 - 211 IPR018520

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
voltage-gated calcium channel complex A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

1 GO annotations of biological process

Name Definition
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDDAVCPTET DNVQNKQKAT TPKRTQRRGG KQQLDRPERA LFCLTLKNPL RIFCIKIVDS
70 80 90 100 110 120
KLFEYFILLT IFANCVALAV YTPYPSGDSN ITNQMLEKIE YIFLVIFTSE CVMKIIAYGF
130 140 150 160 170 180
VLHTGSYLRN GWNFLDFFIV VIGMISTALS NLVKEGFDVK ALRAFRVLRP LRLVSGVPSL
190 200 210 220 230 240
QVVLNSILKA MIPLLHIALL VLFVIIIYAI IGLELFSGKL HKTCRHSNTG EYLNDLDELH
250 260 270 280 290 300
ACGVGFKCPS GYECFDDWVG PNDGITNFDN FGLSMLTVFQ CITLEGWTDV LYSIQDAMGS
310 320 330 340 350 360
SWEWIYFVSM VILGAFFVMN LILGVLSGEF SKERTKAKNR GDFQKLREKQ QIEEDLRGYL
370 380 390 400 410 420
DWITQAEDIE PDPDAQIIED CHKNKVKEVV SIDNLKDHEN ETQQTDSWFR SQKKYLERIN
430 440 450 460 470 480
RRIRRACRKA VKSQAFYWLI ILLVFLNTGV LATEHYRQPI WLDQFQEYTN IFFIALFTCE
490 500 510 520 530 540
MILKMYSLGF QGYFVSLFNR FDCFVVIGSI SEMVLTSSEL MAPLGVSVLR CVRLLRVFKV
550 560 570 580 590 600
TKYWHSLSNL VASLLNSIQS IASLLLLLFL FIVIFGLLGM QVFGGRFTFK PEEEKPRSNF
610 620 630 640 650 660
DSFYQSLLTV FQILTGEDWN VVMYDGIRAY GGVFSFGIVA CIYYIILFIC GNYILLNVFL
670 680 690 700 710 720
AIAVDNLADA DSLSTIEKED ESQIQLDNQI KNEMENEEYL QNGDHISFKA EFGADLDTYL
730 740 750 760 770 780
QDEECGSYSD DENTYNKLGG VKQRVSSLPR RNTNTDMDRI KKDIPYGTSF FIFSHTNRFR
790 800 810 820 830 840
IFCHRLCNHS NFGNFILCCI MFSSAMLAAE NPLKADASRN IVLNKFDYFF TAVFTIELVL
850 860 870 880 890 900
KLISYGFVLH DGAFCRSAFN LLDLLVVCVS LISIFFNSNA ISVVKILRVL RVLRPLRAIN
910 920 930 940 950 960
RAKGLKHVVQ CVIVAVKTIG NIVLVTCLLQ FMFAVIGVQL FKGKFFSCSD GSKVYESDCH
970 980 990 1000 1010 1020
GTYLFYENGD INKPRLKERE WKNNKFHFDD VAKAMLTLFT VSTFEGWPTL LYVSIDSNKE
1030 1040 1050 1060 1070 1080
NGGPIYNFRP IVAAYYIIYI IIIAFFMVNI FVGFVIVTFQ NEGEQEYKNC ELDKNQRNCI
1090 1100 1110 1120 1130 1140
EFALKAKPVR RYIPKHSIQY KVWWFVTSSS FEYSIFVLIM INTVTLAMKF YKQPEYYSEI
1150 1160 1170 1180 1190 1200
LDALNMIFTA VFSLEFIFKL AAFRFKNYFG DAWNTFDFII VLGSFIDIVY SEIKTKEQAL
1210 1220 1230 1240 1250 1260
ATCDGQSCNK AKGGSTLISI NFFRLFRVMR LVKLLSKGEG IRTLLWTFIK SFQALPYVAL
1270 1280 1290 1300 1310 1320
LIVMLFFIYA VIGMQVFGKI MLEEGTSIDR NNNFQTFPQA VLVLFRSATG EAWQEIMMAC
1330 1340 1350 1360 1370 1380
SPRDDVKCDP ESDAVNNCGS SIAFPYFISF YVLCSFLIIN LFVAVIMDNF DYLTRDWSIL
1390 1400 1410 1420 1430 1440
GPHHLDEFIR LWSEYDPDAK GRIKHLDVVT LLRKISPPLG FGKLCPHRMA CKRLVSMNMP
1450 1460 1470 1480 1490 1500
LNSDGTVLFN ATLFAVVRLP LAIKTDGNID EANAELRATI KQIWKRTNPR LLDQVVLTGN
1510 1520 1530 1540 1550 1560
DDEVTVGKFY ATYLIQDYFR RFKKRKEQEG KCDQTENAVT LQAGLRTLQQ NSPALKRTIS
1570 1580 1590 1600 1610 1620
GYLDELASEA DPMHRRHHSL FGKVMSSLLR HEEITSSKIK HLSRTKTIPY QVEFLQHKVQ
1630 1640 1650 1660 1670 1680
LERNKDCLTS ASDDISIEKI IRKQNKYNGQ YFNSEANFMD NIKYTPRYDG EEYEMEDPKS
KDKDEEF