Q253I4
Gene name |
glyA |
Protein name |
Serine hydroxymethyltransferase |
Names |
SHMT, Serine methylase |
Species |
Chlamydia felis (strain Fe/C-56) (Chlamydophila felis) |
KEGG Pathway |
cfe:CF0782 |
EC number |
2.1.2.1: Hydroxymethyl-, formyl- and related transferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q253I4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q253I4-F1 | Predicted | AlphaFoldDB |
No variants for Q253I4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q253I4 | |||||
No associated diseases with Q253I4
3 regional properties for Q253I4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| binding_site | Serine hydroxymethyltransferase, pyridoxal phosphate binding site | 281 - 297 | IPR019798 |
| domain | Serine hydroxymethyltransferase-like domain | 42 - 136 | IPR039429-1 |
| domain | Serine hydroxymethyltransferase-like domain | 171 - 442 | IPR039429-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.2.1 | Hydroxymethyl-, formyl- and related transferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glycine hydroxymethyltransferase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glycine biosynthetic process from serine | The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine. |
| tetrahydrofolate interconversion | The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASLLHKFLE | NASGKKGQDL | ASTAYLAALD | HLLHSFPSIG | KSVIDELKSQ | RSRLKMIASE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NYSSISVQLA | MGNLLTDKYC | EGSPFKRFYS | CCENVDAIEW | ECAETAKELF | GAESAFVQPH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGADANLLAI | MAIITQKIQG | PAVKRLGYKT | INDLTDKEYA | ELKAEIGSHV | CLGPSLNSGG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HLTHGNVRLN | VMSKLMRCLP | YEVSKKTELF | DYAEIARLVR | THKPTVLIAG | YSSYSRRLNF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SILKQIADDC | GAVLWVDMAH | FAGLVAGGVF | VEEENPIPFA | DIVTTTTHKT | LRGPRGGLML |
| 310 | 320 | 330 | 340 | 350 | 360 |
| STKEYEGMIN | RACPLMMGGP | LPHVIAAKAI | ALKEALTVDF | KKYAHQVVDN | ARTLAEHFQK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HGLRLLTGGT | DNHMLIIDLT | SLGIPGNVAE | DILSSVGIAV | NRNTIPSDSE | GVWRTSGIRL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GTPALTSLGM | GSDEMEEVAN | IIVKVLRNIT | LRRNADDNFS | KSEGELPENI | AQEAKARVAD |
| 490 | |||||
| LLARFPLYPE | IDLETLV |