Q25378

PR
Gene name
PKC1
Protein name
Protein kinase C
Names
Species
Lytechinus pictus (Painted sea urchin)
KEGG Pathway
EC number
2.7.11.13: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

255-338 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

466-489 (Activation loop from InterPro)

Target domain

325-583 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q25378

Entry ID Method Resolution Chain Position Source
AF-Q25378-F1 Predicted AlphaFoldDB

No variants for Q25378

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q25378

No associated diseases with Q25378

12 regional properties for Q25378

Type Name Position InterPro Accession
domain C2 domain 149 - 268 IPR000008
domain Protein kinase domain 325 - 583 IPR000719
domain AGC-kinase, C-terminal 584 - 654 IPR000961
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 27 - 78 IPR002219-1
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 92 - 144 IPR002219-2
active_site Serine/threonine-protein kinase, active site 445 - 457 IPR008271
binding_site Protein kinase, ATP binding site 331 - 354 IPR017441
domain Protein kinase, C-terminal 605 - 644 IPR017892
domain Diacylglycerol/phorbol-ester binding 25 - 39 IPR020454-1
domain Diacylglycerol/phorbol-ester binding 41 - 50 IPR020454-2
domain Diacylglycerol/phorbol-ester binding 54 - 65 IPR020454-3
domain Diacylglycerol/phorbol-ester binding 131 - 143 IPR020454-4

Functions

Description
EC Number 2.7.11.13 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium-dependent protein kinase C activity Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNSTLEMKG FARRGALRQK NVHEIKNHKF IPRFFKQPTF CSHCKDFIWG FGKQGFQCKV
70 80 90 100 110 120
CSFVVHKRCH EFVTFQCPGL DPGVDSDDPR NKHKFKVHSY NSPTFCDHCG SLLYGLYHQG
130 140 150 160 170 180
MKCGACDMNV HKRCQKSVPN LCGADHTERR GRIKVKAEVI GNKLQVTVAE AKNLIPMDPN
190 200 210 220 230 240
GLSDPFVKLK LIPDQKRETK KKTRTIKGSL NPTWGESFDF NLEDTDRNRR LLVEVWDWDR
250 260 270 280 290 300
ATRNDFMGAL SFGISELMKA GVDAWYKLLG QEEGEYYNVP AIAETESIDE LTSNIKKLPM
310 320 330 340 350 360
PTQEHVKPQN SNSMSGMGVV RASDFNFLSV LGKGSFGKVM LAEKKGTDEL YAIKILKKDV
370 380 390 400 410 420
IIQDDDVECT MTEKRVLGLP SKPAFLTALH SCFQTMDRLF FVMEFVNGGD LMFQIQKVGK
430 440 450 460 470 480
FREPHAVFYA AEIAVGLFYL HSQGVIYRDL KLDNVLVDAE GHIKIADFGM CKEHMNEGDT
490 500 510 520 530 540
TRTFCGTPDY IAPEIVAYQP YGKAVDWWAF GVLLYEMLAG QPPFDGEDED ELFQSIMEHV
550 560 570 580 590 600
PSYPKSMSRE SVTMCKGFLT KHPGKRLGSG PTGEQDIREH QFFRRIDWEK LANREIQPPF
610 620 630 640 650
VPSVRNPRAA ENFDPYFTKI PCALTPTDKL IIMNIQDEFQ GFTFVNEVFD GYVRSLPS