AiPD: Autoinhibited Protein Database

Gene name	XRCC1
Protein name	DNA-repair protein XRCC1
Names	AtXRCC1, Homolog of X-ray repair cross complementing 1
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G80420
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

131-212 (Predicted disordered autoinhibitory region) PR

131-212 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q24JK4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_1_30237083_C_A	27	K>N	No	1000Genomes
ENSVATH05179290	35	E>K	No	1000Genomes
ENSVATH05179289	36	E>D	No	1000Genomes
tmp_1_30236983_T_C	61	K>E	No	1000Genomes
ENSVATH13844113	73	F>V	No	1000Genomes
tmp_1_30236816_G_A	83	S>L	No	1000Genomes
tmp_1_30236811_C_T	85	A>T	No	1000Genomes
tmp_1_30236769_C_T	99	G>S	No	1000Genomes
tmp_1_30236686_C_A	126	K>N	No	1000Genomes
tmp_1_30236505_T_C	157	S>G	No	1000Genomes
ENSVATH13844108	181	T>K	No	1000Genomes
ENSVATH00800239	205	F>S	No	1000Genomes
tmp_1_30236053_G_A	220	T>I	No	1000Genomes
tmp_1_30236054_T_A	220	T>S	No	1000Genomes
tmp_1_30235935_G_A	233	P>L	No	1000Genomes
tmp_1_30235932_C_G	234	G>A	No	1000Genomes
ENSVATH13844103	254	S>F	No	1000Genomes
ENSVATH05179282	269	S>C	No	1000Genomes
tmp_1_30235664_A_G	281	M>T	No	1000Genomes
tmp_1_30235450_A_T	352	C>*	No	1000Genomes
ENSVATH14496391	352	C>Y	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	BRCT domain	58 - 146	IPR001357
domain	XRCC1, first (central) BRCT domain	65 - 144	IPR045080

		Description
EC Number
Subcellular Localization	Nucleus	Accumulates at sites of DNA damage
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
damaged DNA binding	Binding to damaged DNA.
double-stranded methylated DNA binding	Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.

Name	Definition
base-excision repair	In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
DNA demethylation	The removal of a methyl group from one or more nucleotides within an DNA molecule.
DNA ligation	The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.
double-strand break repair via nonhomologous end joining	The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
positive regulation of DNA-5-methylcytosine glycosylase activity	Any process that activates or increases the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity.
positive regulation of polynucleotide 3'-phosphatase activity	Any process that activates or increases the frequency, rate or extent of polynucleotide 3'-phosphatase activity.
single strand break repair	The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins