Q24740

PR
Gene name
Cdc37 (GJ12421)
Protein name
Hsp90 co-chaperone Cdc37
Names
Hsp90 chaperone protein kinase-targeting subunit
Species
Drosophila virilis (Fruit fly)
KEGG Pathway
dvi:6624466
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

91-174 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q24740

Entry ID Method Resolution Chain Position Source
AF-Q24740-F1 Predicted AlphaFoldDB

No variants for Q24740

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q24740

No associated diseases with Q24740

3 regional properties for Q24740

Type Name Position InterPro Accession
domain Cdc37, N-terminal domain 1 - 121 IPR013855
domain Cdc37, C-terminal 282 - 375 IPR013873
domain Cdc37, Hsp90 binding 114 - 278 IPR013874

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
insulin receptor binding Binding to an insulin receptor.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

2 GO annotations of biological process

Name Definition
positive regulation of insulin receptor signaling pathway Any process that increases the frequency, rate or extent of insulin receptor signaling.
positive regulation of neuroblast proliferation Any process that activates or increases the rate of neuroblast proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVDYSKWKNI EISDDEDETH PNIDTPSLFR WRHQARVERM AESEKEKEEL KKKRQSYQAR
70 80 90 100 110 120
LINVKELISK KEGDEVALKK ELEKIENEGK ELDRQENELL KREKKTPWNV DTISKPGFEK
130 140 150 160 170 180
TVINKKPPRK AAEDLTEEER EQRMKQFVKE NEKLCKQYGM LRKYDDSKRF LQEHLDLVCE
190 200 210 220 230 240
ETANYLVIWS INLEMEEKHD LMAHVAHQCI CMQYILELAK QLDVDPRACV SSFFSKIQQC
250 260 270 280 290 300
VPEYRQQFES EIEGFKERIQ KRAQEKLQEA MAQLEEEEKQ ERMGPGGLDP ADVFESLPEE
310 320 330 340 350 360
LKACFESRDI ELLQKTIATM PVDQAKYHMK RCVDSGLWVP NAADVQLGND ETEAKDDETT
370 380 390
TATNETPTEK ENSKSQNEKS ADAAKEEPLY AGVSTDDVD