Q24247

PR
Gene name
mew (CG1771)
Protein name
Integrin alpha-PS1
Names
Position-specific antigen subunit alpha-1, Protein multiple edematous wings
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG1771
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

94-164 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q24247

Entry ID Method Resolution Chain Position Source
AF-Q24247-F1 Predicted AlphaFoldDB

No variants for Q24247

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q24247

No associated diseases with Q24247

9 regional properties for Q24247

Type Name Position InterPro Accession
repeat FG-GAP repeat 321 - 357 IPR013517-1
repeat FG-GAP repeat 380 - 413 IPR013517-2
repeat Integrin alpha beta-propellor 38 - 112 IPR013519-1
repeat Integrin alpha beta-propellor 121 - 186 IPR013519-2
repeat Integrin alpha beta-propellor 193 - 245 IPR013519-3
repeat Integrin alpha beta-propellor 263 - 429 IPR013519-4
repeat Integrin alpha beta-propellor 432 - 494 IPR013519-5
domain Integrin alpha-2 479 - 1006 IPR013649
conserved_site Integrin alpha chain, C-terminal cytoplasmic region, conserved site 1107 - 1114 IPR018184

Functions

Description
EC Number
Subcellular Localization
  • Apical cell membrane ; Single-pass type I membrane protein
  • Lateral cell membrane ; Single-pass type I membrane protein
  • Basal cell membrane ; Single-pass type I membrane protein
  • During mid-oogenesis, localizes to the apical, to the lateral and to the basal membranes of follicle cells
  • Apical membrane localization peaks at oogenesis stages 9 and 10A in columnar follicle cells overlying the oocyte while decreases in the most posterior follicle cells
  • Localization to lateral and basal membranes persists during dorsal appendage morphogenesis, although diminished and often absent
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basal plasma membrane The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
lateral plasma membrane The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.

4 GO annotations of molecular function

Name Definition
cell adhesion molecule binding Binding to a cell adhesion molecule.
extracellular matrix binding Binding to a component of the extracellular matrix.
integrin binding Binding to an integrin.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.

22 GO annotations of biological process

Name Definition
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
apposition of dorsal and ventral imaginal disc-derived wing surfaces The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing.
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
axonal defasciculation Separation of axons away from a bundle of axons known as a fascicle.
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell adhesion mediated by integrin The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cell-cell adhesion The attachment of one cell to another cell via adhesion molecules.
cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules.
ectodermal digestive tract morphogenesis The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm.
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
imaginal disc-derived wing morphogenesis The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
integrin-mediated signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
maintenance of epithelial integrity, open tracheal system Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process.
midgut development The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
muscle attachment The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
salivary gland boundary specification Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland.
salivary gland development The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
salivary gland morphogenesis The process in which the anatomical structures of the salivary gland are generated and organized.
sensory perception of smell The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
substrate adhesion-dependent cell spreading The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P23229 ITGA6 Integrin alpha-6 Homo sapiens (Human) PR
P26006 ITGA3 Integrin alpha-3 Homo sapiens (Human) PR
10 20 30 40 50 60
MLELPFTTIR PNCRLRQNLG ILIILQCVLT CYNFNLEQRL PIVKYGHPHS HFGYSVATHT
70 80 90 100 110 120
IGEANGPNKT NCVLVGAPLD QNRQPNTTHS GALWRCPMTQ RFDDCEQVIT DGRRNFDSEI
130 140 150 160 170 180
LSPPGNDEIK EDQWMGVTVR SNPLQANGSG GKVIVCAHRY MYIVRENRYG QGLCYLLTND
190 200 210 220 230 240
LQFEEVHEPC KGRPVQRQHE DYGLCQAGTS AALLDDDTMV LGSPGPYTWR GSIWVTQVGG
250 260 270 280 290 300
EYLQRDKTTY YSDHSDLNSP VDKYSYLGMS VTGGRFFGHM SYAAGAPRSE GHGQVVIFDK
310 320 330 340 350 360
STDNPIPVHS ILDGEQFGSS FGYELATADI NGDHRPDLIV AAPLYFTKTE GGAVYVYQNI
370 380 390 400 410 420
QDTLPMKYTL KLTGPLESRF GLALANIGDL NKDNCEDLAV GAPYEGNGVV YIYLGSSQGL
430 440 450 460 470 480
NSKPAQKIQA SELGGTIPNG QPIRTFGISI SGNTDLDDNS YPDVVIGAFN SSAAVILLAR
490 500 510 520 530 540
PIISIQTSVQ RKELHNMDPN TPGCLDDPAS NLTCFTFRAC CSIEPYDEKN KELRLAYSVE
550 560 570 580 590 600
AETFDHLKKF SRVFFFDREN KRTNVLSRVV RVHTNGRTEC QAVTGYIKAN TRDIQTPVRF
610 620 630 640 650 660
RLKYSLVEPP LADSALVRLN PILDQTQAHV DFEGTFQKDC GDDDLCESNL IIRVEPNITE
670 680 690 700 710 720
SSGNEYTLIL DETELEVRIN VSNLADSAYE AQLFIAHQAG VSYVATKKPT NATCNSYNTT
730 740 750 760 770 780
LVACSLGNPM LRDTTTFVTI RFQPKGLEPS EKIMLFHIFA NTTSKLVGPE RPERDLRVNV
790 800 810 820 830 840
VRRAKLNFRG WAIPEQSFYS GSSVANSVAN TAATDIEGHG PMGMDDVGSQ VHHMFTIFNE
850 860 870 880 890 900
GPSTAPKVQM VIHWPYSLYS DPQSGRPVQY LLYLEQVPTV EVSQGECHVA KEYVNPLNLA
910 920 930 940 950 960
SGSRENPAYL SAPAQMRMFP SQSRHSFNKS LIHSQRSYYS SSHRDDHSDD TQSNRNRVRR
970 980 990 1000 1010 1020
SFLERVTRLE RLMYDPESSN AANGKKQDIV ELDCNKGATN CVRIECDILN MPALSEAQVV
1030 1040 1050 1060 1070 1080
VKARLWNSTL VSEYPRVERV RIFSTATAQI PESYGVEVMD HNNIEVETRA YPELRNQQRD
1090 1100 1110 1120 1130 1140
TSIPWLIIIL GIVGGLLLLA LVTYVLWKVG FFKRIRPTDP TLSGNLEKMN EEKPFLAPSK
NTHHVF