Q22639

PR
Gene name
vps-54
Protein name
Vacuolar protein sorting-associated protein 54
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_T21C9.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

76-158 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q22639

Entry ID Method Resolution Chain Position Source
AF-Q22639-F1 Predicted AlphaFoldDB

No variants for Q22639

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q22639

No associated diseases with Q22639

2 regional properties for Q22639

Type Name Position InterPro Accession
domain Vacuolar protein sorting-associated protein 54, C-terminal 819 - 948 IPR012501
domain Vacuolar protein sorting-associated protein 54, N-terminal 301 - 460 IPR019515

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus, trans-Golgi network
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GARP complex A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.

1 GO annotations of molecular function

Name Definition
syntaxin binding Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.

3 GO annotations of biological process

Name Definition
Golgi to vacuole transport The directed movement of substances from the Golgi to the vacuole.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSMDDRTVG LISASSSRAS LKIQPEIGYP RICDYCQPII ELMTASEFAR HIRQDHTTKE
70 80 90 100 110 120
GGSFLCRYGE HGVCQKLPLE GVCDLDFEAH IRRCHTSSQP AGYSSPTSSL VASYTEDSEE
130 140 150 160 170 180
TASLRSIRLT SDRDTPTIEK KKFTLHSFTQ NLSAVLADPS RSRSDLTTFF TRHWGDSFVP
190 200 210 220 230 240
TQPVPQSKRL ARLADSAFDS YCQSAGESYR RYQAIKRALR LSHADGGVGI GDERQDAEDL
250 260 270 280 290 300
PTIFIDPRFT LGDSSTFSDV FTVPANDDLD ALKQTLSGRN VIPATPLEIA TNRKPGEFRD
310 320 330 340 350 360
YEALQNRLEM MHDVVDGRLA GKLVAKTDDF WQVVRSYSGL QEQLANALQC VMVVRKNLKR
370 380 390 400 410 420
VDELVCDQSK KIVEVHERYE QKKKLLAKLH DISCLREAQS TVQMMLSQGD YPKAIECIET
430 440 450 460 470 480
SLDVLSKELN GVTCFRHLAS QLRELYTVIG RMMNEDFASL IQKELGVKPE AGTMIQAEGE
490 500 510 520 530 540
LSAVLLGLMR MRKYSFIAVL REEIIEGVKS VMRQVIKNQI LNNGVDLNDF DPSLTQLGEP
550 560 570 580 590 600
VRRMKHADFL KTVKAVMDEE FYFCKRLEAL QDILLETVER ANPLHRHGSE DIIVERIEEA
610 620 630 640 650 660
KDIHESESDD EVGTTFSKSA SSGGFSVGGS ALSSNASATT LLSIEVRSEA FLRHVLPLIA
670 680 690 700 710 720
EFGHQCAQQR ISRLLIARAK NASVTEATTP TQLSECIKLV KEFQSKCDKE GWYSTQNQKV
730 740 750 760 770 780
GGLGRSVNKL SMDYIEKFHA ARKIRIGNML DTELWKATDV SIVDQNIVDM AMETGQLRNT
790 800 810 820 830 840
KRIDDGPIKK SFKRTESAVT IDSTTSTSNQ IQGVIVDEEN YVVVGSSITM IQLLSDYCEA
850 860 870 880 890 900
ISEMPSFSQD WNSRVVELLK TFNSRCCQLI LGAGALQLVG LKTISVRNLA LAGRSLELVC
910 920 930 940 950 960
RFIPMVHDEM DRVLPENRKS LLRYFKQVES EYRDHVNEIA AKLISVIAHY TTNCLGMWDV
970 980 990 1000 1010 1020
KGVIPSPEFQ QICRHMLKFH NGLVGIMPRD QIEALFRQVH ENFKANLREH VTGMGITPHD
1030 1040 1050
PLKYGYVTKD YMFYQQNVKN MESCRNLELE SLNDIMFE