Q21NW5
Gene name |
thyA |
Protein name |
Thymidylate synthase |
Names |
TS, TSase |
Species |
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) |
KEGG Pathway |
sde:Sde_0350 |
EC number |
2.1.1.45: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q21NW5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q21NW5-F1 | Predicted | AlphaFoldDB |
No variants for Q21NW5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q21NW5 | |||||
No associated diseases with Q21NW5
1 regional properties for Q21NW5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thymidylate synthase/dCMP hydroxymethylase domain | 2 - 277 | IPR023451 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.45 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| thymidylate synthase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| dTMP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). |
| dTTP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKQYLDLMRH | VRDTGTKKED | RTGTGTVSVF | GYQMRFDLSE | GFPLVTTKKC | HLKSIIHELL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WFLKGETNTQ | YLTDNGVRIW | NEWATEEGDL | GPVYGAQWRS | WPTPDGGSLD | QFALLVEQIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NKPDSRRHII | SAWNPALLPD | EGVSPQDNVR | NGKMALPPCH | TLFQFYVADN | KLSCQLYQRS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ADIFLGVPFN | IASYALLTMM | VAQVTGLELG | DFVHTFGDAH | LYLNHLEQVE | TQLAREPLPL |
| 250 | 260 | 270 | |||
| PTMKINPEVK | DIFSFKFEDF | ELVDYQAHPH | ISAPISI |