Q21489

PR
Gene name
chl-1
Protein name
ATP-dependent DNA helicase chl-1
Names
Chromosome loss protein homolog
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_M03C11.2
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

63-202 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q21489

Entry ID Method Resolution Chain Position Source
AF-Q21489-F1 Predicted AlphaFoldDB

No variants for Q21489

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q21489

No associated diseases with Q21489

4 regional properties for Q21489

Type Name Position InterPro Accession
domain Helicase-like, DEXD box c2 type 2 - 395 IPR006554
domain ATP-dependent helicase, C-terminal 634 - 803 IPR006555
domain RAD3-like helicase, DEAD 188 - 373 IPR010614
domain Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type 1 - 403 IPR014013

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.

4 GO annotations of biological process

Name Definition
DNA duplex unwinding The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
establishment of sister chromatid cohesion The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDEFSFPFQP YDIQLNLMRE IRQCIEQRKI GIFESPTGTG KSLSVLCSTM TWLEAEELRI
70 80 90 100 110 120
STDLSTRLGE VHTKITECDK ITTADNWETA VREKMRAQDV ETEILEQIQS RERLQSRIDQ
130 140 150 160 170 180
ARRGMVEVSR KRKAPARDTD QFLEPQDEAA PSEEYNNDEK SEKQRDSDFF DDVDEEEEKP
190 200 210 220 230 240
LKCLKIFYAS RTHSQLEQLA EELAKTRFQP RIVTCASRGT LCVNEEVKKL KLNHLINEKC
250 260 270 280 290 300
MELRKNGMSE KEKVQKLEKG TTKKTKTCAT SCEFYNSTQI EDVVNGVLSN KLKSTLEVSK
310 320 330 340 350 360
QGKLSNGCPY FATRKSVPQC QLVLLPYQVL LHDGTRKAWG IELKDNVIVL DEAHNVLNTI
370 380 390 400 410 420
SSLYSAEIST KSLTLALRLI REYNAHYKLK LLAHNLLYMK QLESLTSKML IFLNSQSKED
430 440 450 460 470 480
VMTMAQLARN LNILEINLFK LAEYMEKTDL CKKFHGFYMR LQKEEIKKEN EKPKLTGIQK
490 500 510 520 530 540
LMAAKEAEPE PEAEPLPPPK PVPSPLFSLK SFIDALTNKC EDGRIIVEKS ATEAKFRFML
550 560 570 580 590 600
LNPADRLSEV VTSARATILV GGTMEPAQLL VETLSRGSIG ADSIRRFSCC HVIDDSQLLA
610 620 630 640 650 660
VTVERTVDGK PFQLTYQTRG ADTTLRSLAT SIQALIPHIP NGVVIFVPSY DFLFNFQKKM
670 680 690 700 710 720
KEFGILKRIE EKKAVFTESR QPTSDVWDRF SRAAKTSKGA ILFAVVGGKM SEGINFCDEL
730 740 750 760 770 780
GRAVIVIGLP YPNKTSVELR ERMKFLDTQM PNGGNLLYES LCMHAVNQAI GRAIRHRRDY
790 800 810 820
AAVYLFDDRY AKESTRRKLS TWIGDRTQVK LGFGEIIRKT RSFFEANSKK