AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-79 (Predicted disordered autoinhibitory region) PR

1-79 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q21252-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for Q21252

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	387 - 666	IPR000719
active_site	Serine/threonine-protein kinase, active site	513 - 525	IPR008271
binding_site	Protein kinase, ATP binding site	393 - 416	IPR017441

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

Name	Definition
metalloendopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9DER7	TLL1	Tolloid-like protein 1	Gallus gallus (Chicken)	PR
P25723	tld	Dorsal-ventral patterning protein tolloid	Drosophila melanogaster (Fruit fly)	PR
O43897	TLL1	Tolloid-like protein 1	Homo sapiens (Human)	PR
P98066	TNFAIP6	Tumor necrosis factor-inducible gene 6 protein	Homo sapiens (Human)	PR
P13497	BMP1	Bone morphogenetic protein 1	Homo sapiens (Human)	PR
Q9Y6L7	TLL2	Tolloid-like protein 2	Homo sapiens (Human)	PR
P98063	Bmp1	Bone morphogenetic protein 1	Mus musculus (Mouse)	PR
Q9WVM6	Tll2	Tolloid-like protein 2	Mus musculus (Mouse)	PR
O08859	Tnfaip6	Tumor necrosis factor-inducible gene 6 protein	Mus musculus (Mouse)	PR
Q62381	Tll1	Tolloid-like protein 1	Mus musculus (Mouse)	PR
Q6HA09	Astl	Astacin-like metalloendopeptidase	Mus musculus (Mouse)	PR
P55112	nas-4	Zinc metalloproteinase nas-4	Caenorhabditis elegans	PR
P55113	nas-7	Zinc metalloproteinase nas-7	Caenorhabditis elegans	PR
P55115	nas-15	Zinc metalloproteinase nas-15	Caenorhabditis elegans	PR
Q18439	nas-8	Zinc metalloproteinase nas-8	Caenorhabditis elegans	PR
Q20176	nas-39	Zinc metalloproteinase nas-39	Caenorhabditis elegans	PR
Q20942	nas-38	Zinc metalloproteinase nas-38	Caenorhabditis elegans	PR
Q9U3S9	nas-6	Zinc metalloproteinase nas-6	Caenorhabditis elegans	PR
O62243	nas-1	Zinc metalloproteinase nas-1	Caenorhabditis elegans	PR
Q22398	nas-22	Zinc metalloproteinase nas-22	Caenorhabditis elegans	PR
O57460	tll1	Dorsal-ventral patterning tolloid-like protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR