Q20719

PR
Gene name
F53F4.10
Protein name
Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F53F4.10
EC number
7.1.1.2: Hydron translocation or charge separation linked to oxidoreductase reactions
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q20719

Entry ID Method Resolution Chain Position Source
AF-Q20719-F1 Predicted AlphaFoldDB

No variants for Q20719

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q20719

No associated diseases with Q20719

1 regional properties for Q20719

Type Name Position InterPro Accession
domain NuoE domain 118 - 197 IPR042128

Functions

Description
EC Number 7.1.1.2 Hydron translocation or charge separation linked to oxidoreductase reactions
Subcellular Localization
  • Mitochondrion inner membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

3 GO annotations of molecular function

Name Definition
2 iron, 2 sulfur cluster binding Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
metal ion binding Binding to a metal ion.
NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).

1 GO annotations of biological process

Name Definition
mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLASNVLLQ ASRLGEMVIK RGGATGLMVH RDTKENNLNV KFKFTSENQE RIKAIMDIYP
70 80 90 100 110 120
EGHKAGALIP LLDLAQRQHG WLPISAMHEV AKILEVPRMR AYEVATFYTM FNRQPVGKYF
130 140 150 160 170 180
LQVCATTPCM LRGAETITET IEKKLGIHAG ETTKDGLFTL AEVECLGACV NAPMIQINDD
190 200 210 220 230
YFEDLTPKDV NEILDDLKAG RKPAAGPRSG RLAAEPFGEL TSLKETPPGP GFGLQAALK