Q1WVA5

PR
Gene name
rpoB
Protein name
DNA-directed RNA polymerase subunit beta
Names
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta
Species
Ligilactobacillus salivarius (strain UCC118) (Lactobacillus salivarius)
KEGG Pathway
lsl:LSL_0197
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

766-842 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1WVA5

Entry ID Method Resolution Chain Position Source
AF-Q1WVA5-F1 Predicted AlphaFoldDB

No variants for Q1WVA5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1WVA5

No associated diseases with Q1WVA5

7 regional properties for Q1WVA5

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 587 - 973 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 826 - 838 IPR007121
domain RNA polymerase Rpb2, domain 7 975 - 1049 IPR007641
domain RNA polymerase Rpb2, domain 2 139 - 322 IPR007642
domain RNA polymerase, beta subunit, protrusion 27 - 368 IPR007644
domain RNA polymerase Rpb2, domain 3 381 - 449 IPR007645
domain DNA-directed RNA polymerase, beta subunit, external 1 domain 459 - 526 IPR019462

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNNLAGHLVK YGKHRVRRSY SRIKEVLDLP NLIEVQTDSY KWFLDEGLRE MFDDIMPIED
70 80 90 100 110 120
FQGKLSLEFV DYQLLEPKYT VEEARQHDAN YSAPLHVTLR LINHETGEIK SQDVFFGDFP
130 140 150 160 170 180
LMTKQGTFII NGAERVIVSQ LVRSPGVYFN SELDKNGRTN YGTTVIPNRG AWLEYETDAK
190 200 210 220 230 240
NVAYVRIDRT RKIPLTELIR ALGYGSDNEI VEILGSNSDS LMLTLEKDVH KNMDDSRVEE
250 260 270 280 290 300
SLKDIYERLR PGEPKTADSS RSLLTARFFD PKRYDLAPVG RYKINKKLDL KTRLLNLTVA
310 320 330 340 350 360
ETLADPDTGE IIVNKDEVID KQVMDKLAPY LARDDFKTFT FHPSEEGVVQ EPMTLQIVKV
370 380 390 400 410 420
YSPKDPEKVV NVIGNANVDI QFKHITPADI VASMNYFFNL QEGMGSTDDI DHLGNRRTRS
430 440 450 460 470 480
VGELLQNQFR IGLSRMERVV RERMSIQDTS TVTPQQLINI RPVVASIKEF FGSSQLSQFM
490 500 510 520 530 540
DQTNPLGELS HKRRFSALGP GGLTRDRAGY EVRDVHYTHY GRMCPIETPE GPNIGLINSL
550 560 570 580 590 600
SSYARINKYG FVETPYRRVS WETHKVTDKI DYLTADEEDN YVIAQANSPL NDDGSFVDDV
610 620 630 640 650 660
VMARKKDDDV EISTEKVDYM DVSPKQVVAV ATACIPFLEN DDSNRALMGA NMQRQAVPLI
670 680 690 700 710 720
KPHAPLVGTG IEYKAAHDSG VALISEHEGT VEYVDAREIR VRRDDGSLDK YKLMKFHRSN
730 740 750 760 770 780
GGKNYNQTPI VRVGDRVDAD EVLADGPAME NGELALGQNP LIAFMTWDGY NFEDAIAINE
790 800 810 820 830 840
RLVKEDVYTS IHIEEHESEA RDTKLGPEEI TREIPNVGED ALKNLDEFGI IRIGAEVKDG
850 860 870 880 890 900
DILVGKVTPK GVTELSAEER LLHAIFGEKA REVRDTSLRV PHGAGGIVQD VKIFTREGGD
910 920 930 940 950 960
ELSPGVNMMV RVYIAQKRKL QVGDKMAGRH GNKGTVSVVI PEEDMPFMPD GTPIDIMLSP
970 980 990 1000 1010 1020
MGVPSRMNIG QVLDLHLGMA ARKLGIHVAS PVFDGARDED IWSALQEAGL PGDGKTVLYD
1030 1040 1050 1060 1070 1080
GRTGEAFDNR IAVGVMYYLK LAHMVDDKIH ARSIGPYSLV TQQPLGGKAQ FGGQRFGEME
1090 1100 1110 1120 1130 1140
VWALEAYGAA YTLQEILTYK SDDVVGRVKT YEAIVKGEPI PKPGVPESFR VLVKELQALG
1150 1160 1170 1180 1190
MDMKVLDADK NEIELRDMDD EDDDIVNVDA LKKFAKEQEE KKAKEAEQET AEKEETKTE