Q1RHT8

PR
Gene name
gyrB
Protein name
DNA gyrase subunit B
Names
Species
Rickettsia bellii (strain RML369-C)
KEGG Pathway
rbe:RBE_0995
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1RHT8

Entry ID Method Resolution Chain Position Source
AF-Q1RHT8-F1 Predicted AlphaFoldDB

No variants for Q1RHT8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1RHT8

No associated diseases with Q1RHT8

6 regional properties for Q1RHT8

Type Name Position InterPro Accession
domain DNA gyrase B subunit, C-terminal 735 - 797 IPR002288
domain Histidine kinase/HSP90-like ATPase 39 - 184 IPR003594
domain TOPRIM domain 429 - 544 IPR006171
domain DNA topoisomerase, type IIA, subunit B, domain 2 231 - 401 IPR013506
conserved_site DNA topoisomerase, type IIA, conserved site 433 - 441 IPR018522
domain DNA gyrase subunit B, TOPRIM domain 429 - 543 IPR034160

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEFEEKLNE SSYGADSIKV LKGLEAVRKR PGMYIGDVGD GSGLHHMIYE VVDNAIDEAL
70 80 90 100 110 120
AGYCDLVRVV LNKNGSVTVS DNGRGIPVEI HEEEGISAAE VIMTQLHAGG KFDQNSYKVS
130 140 150 160 170 180
GGLHGVGVSV VNALSDWLEL RIWRNNTEHL IRFNNGITEA PLAVVKENVD KKGTEVTFFP
190 200 210 220 230 240
SVETFTNIEF DFSIIEHRLR ELAFLNSGVK ILLTDNRFEE VKEVEFYYTG GIEAYVKYLD
250 260 270 280 290 300
RAKHAVHSCI VVNADNTESG ISLELAMHWN DSYHENILCF TNNIRQRDGG THLSAFKSGL
310 320 330 340 350 360
TRVITAYLEN TGLNKKAKNA FSGEDTREGI CCVLSVKVPD PKFSSQTKDK LVSSEVRPIV
370 380 390 400 410 420
ENAVYTKVLE WFEEHPADAK LIINKIMEAA NAREAARKAR ELTRRKSVLE VSNLPGKLAD
430 440 450 460 470 480
CHAKDPAVSE LFIVEGDSAG GTAKQGRDSK IQAILPLRGK ILNVERARFD KMLGSDQIGT
490 500 510 520 530 540
LITALGTGVD NREFSLEKLR YHKVIIMTDA DVDGSHIRTL LLTFFYRHMP ELINKGYLYI
550 560 570 580 590 600
AQPPLYKVKK GASELYLKNE QALQDYLVKS AISDATLTLD NKEQLTNENL EELMSKVIKF
610 620 630 640 650 660
NSLLDHASKK FNRSITEILA INDLLNNKIF DNESDSRLKK ALNALNSLEQ SPDKTDWEVL
670 680 690 700 710 720
KHENKIEFFR FSRGLKERKI LLREQLESFE FINISKLALT IFDVFNKQLK LVVKNQEFDI
730 740 750 760 770 780
LTPSILLNTI IECGKKGISV QRFKGLGEMN SDQLWDTTLD PKKRTLMQVR VAEVDEAEGI
790 800
FSTLMGDVVE PRRQFIQSNA LNVVNLDV