Q1RHA1

PR
Gene name
lepB (RBE_1182)
Protein name
Signal peptidase I
Names
SPase I, Leader peptidase I
Species
Rickettsia bellii (strain RML369-C)
KEGG Pathway
rbe:RBE_1182
EC number
3.4.21.89: Serine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1RHA1

Entry ID Method Resolution Chain Position Source
AF-Q1RHA1-F1 Predicted AlphaFoldDB

No variants for Q1RHA1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1RHA1

No associated diseases with Q1RHA1

3 regional properties for Q1RHA1

Type Name Position InterPro Accession
domain Peptidase S26 44 - 250 IPR019533
active_site Peptidase S26A, signal peptidase I, lysine active site 133 - 145 IPR019757
conserved_site Peptidase S26A, signal peptidase I, conserved site 216 - 229 IPR019758

Functions

Description
EC Number 3.4.21.89 Serine endopeptidases
Subcellular Localization
  • Cell inner membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

1 GO annotations of biological process

Name Definition
signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTMKKLTSTT TTLWDNKLFI NNLKNFMQTN TESNNNKTTA QEWKSFILVV VIALMIRILI
70 80 90 100 110 120
IESFVVPTGS MKATILENDR IFGTKYSYGY SNYSLSFFDF IHLFKGRIFA RTPERGDIII
130 140 150 160 170 180
FRPPHEMNTR YIKRLIGLPG DKVQLIDDVI YINDEKIERV ESGIYVSEEG RKYLKFKETL
190 200 210 220 230 240
PNGKTYFSYK LAPVLGIMFN DKYGNTDAFY VPEGEYFFLG DNRDQSNDSR IDLGFVPFEN
250 260 270 280 290
FIAKAQFIWF STKITWWDSD IGVINLILKL KPWAESIRFN RIFRNLYSIE D