Q1RGX8

PR
Gene name
parC
Protein name
DNA topoisomerase 4 subunit A
Names
Topoisomerase IV subunit A
Species
Rickettsia bellii (strain RML369-C)
KEGG Pathway
rbe:RBE_1305
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

684-736 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1RGX8

Entry ID Method Resolution Chain Position Source
AF-Q1RGX8-F1 Predicted AlphaFoldDB

No variants for Q1RGX8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1RGX8

No associated diseases with Q1RGX8

3 regional properties for Q1RGX8

Type Name Position InterPro Accession
domain DNA topoisomerase, type IIA, domain A 9 - 471 IPR002205
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 602 - 645 IPR006691-1
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 647 - 682 IPR006691-2

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
extrinsic component of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.

2 GO annotations of biological process

Name Definition
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKEAKIENID FGSALSERYL AYALSTIMSR SLPDVRDGLK PVHRRLLYAM LQLRLEPNSG
70 80 90 100 110 120
YKKCARVVGD VIGKYHPHGD VAVYDTLVRL AQHFSLRYPL IDGQGNFGSI DGDNAAAMRY
130 140 150 160 170 180
TESRMTEICT LLMEDIDKDT VDFRSTYDDS DLEPVIMPAS FPNLLANGSE GIAVGMATNI
190 200 210 220 230 240
PPHNLHELCD ALMHLIDHPK AEISDIMNFI KGPDFPTGGI IIDKSDVITS AYMTGRGSFR
250 260 270 280 290 300
VRARWEKEEL NYGVYQIVVT EIPYQVQKSK LIEQIAILLK DKKIPLVSNI RDESTDIIRL
310 320 330 340 350 360
VIEPRDRSCD PQIVMESLFK LTNLESRIQL NMNVIGSNNV PKVMNILEVL QEFLSHRQNI
370 380 390 400 410 420
ITRRSTYLLN KIKHRLEILE GLRIAYLNLD EIIKIIREED EPKAIMMQRF QLTEIQVEAI
430 440 450 460 470 480
LNTRLRSLRK LEEQEIITEH SNLQKQQAIL EEILNNPKEL WKVVKKEIKA VQAKFGLNTT
490 500 510 520 530 540
IGARRTSFEQ VTLTNQVVDI TAFITKEPIT IICSKMGWVR SLKGHNNDLS SIKYKEGDAE
550 560 570 580 590 600
KFILEAYTTD KILIISSEGR FFTLLADNIS KGKGTGESIK LLVDIGNNDI TEILVYKPDH
610 620 630 640 650 660
LLLLASSIGK GFVVNSNEVM AQTKSGKQIM NVPDGHTCIA CLPVNGDSVA CIGESRKLLV
670 680 690 700 710 720
FNIDEIPEMK KGQGVTLQKF KNAKLLDIKI FNREDGLSWN SGGKVKLEKN IIAFLGKRGS
730
TGKLPPMGFP KNNRFS