Q1QZX1

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)
KEGG Pathway
csa:Csal_0625
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

386-458 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1QZX1

Entry ID Method Resolution Chain Position Source
AF-Q1QZX1-F1 Predicted AlphaFoldDB

No variants for Q1QZX1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1QZX1

No associated diseases with Q1QZX1

4 regional properties for Q1QZX1

Type Name Position InterPro Accession
domain DHHA1 domain 723 - 861 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 642 - 687 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 543 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 700 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSADIRQAF LTFFEEHGHT IVPSSSLVPA NDPTLLFTNA GMVPFKDVFL GRDPRPYVRA
70 80 90 100 110 120
TSAQRCVRAG GKHNDLDNVG YTARHHTFFE MLGNFSFGDY FKRGAIRFAW TFLTERLGLP
130 140 150 160 170 180
ADKLWVTVHV SDDEAERIWK DEIGIDPARF SKLDEDNFWQ MGDTGPCGPS SEIFFDHGPE
190 200 210 220 230 240
VAGGPPGSPE EDGDRYIEIW NLVFMQFDRD SAGTLNPLPK PSIDTGMGLE RVAAVLQGVH
250 260 270 280 290 300
SNYEIDLFQN LLNAASEATG YDDTSAPSLR VIADHIRSCA FLITDDVLPS NEGRGYVLRR
310 320 330 340 350 360
IIRRAIRHGH KLGAREPFFH TLVAALDAEM GAAYPELRKA RPRIEKVLLK EEEQFARTLD
370 380 390 400 410 420
HGMGLLTEAL ETLDGEVLPG ETVFKLYDTY GFPFDLTADV CRERGVTLDE VGFQRELEAQ
430 440 450 460 470 480
RERARAASQF GADYTAALDL EGETAFTGYE RLEDEARVTA LVDREGNALA ALEAGQHGVV
490 500 510 520 530 540
VLDRTPFYGE SGGQAGDTGY LEADGMRFQV TDTQKQGGHH LHHGVLVEGR LDVGASVTPR
550 560 570 580 590 600
VDASLRAATM RNHSATHLLH EALRQVLGEH VQQKGSLVTA ERLRFDVSHF EAMTRAQLDE
610 620 630 640 650 660
VERIVNAQIL ANAATRIEHM TLDEAKAKGA AALFEAKYAD SVRVLTIGAD DFSIELCGGT
670 680 690 700 710 720
HVARSGDIGC FHILSEAGVA AGVRRIEAVT GEGALAYFRD QEAKVARVAE QLKAKPEQVE
730 740 750 760 770 780
ARLEATLERN RTLEKELERL KAKLASATSG DMLADVREVA GVKLLAKQVE GVGGKELRGL
790 800 810 820 830 840
LDQLKNKLGS GVIVLGVAGD EKVSLIAGVT DDLTARLKAG DLVKHVAEQV GGKGGGRADM
850 860
AQAGGSRPQA LPDALASVPS WVEARLGE